Biofabrication Methods for Reconstructing Extracellular Matrix Mimetics

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2023 Sep 18

PMID 37719085

Authors

Abdellah Aazmi

Duo Zhang

Corrado Mazzaglia

Mengfei Yu

Zhen Wang

Huayong Yang

Yan Yan Shery Huang

Liang Ma

Affiliations

Soon will be listed here.

Abstract

In the human body, almost all cells interact with extracellular matrices (ECMs), which have tissue and organ-specific compositions and architectures. These ECMs not only function as cellular scaffolds, providing structural support, but also play a crucial role in dynamically regulating various cellular functions. This comprehensive review delves into the examination of biofabrication strategies used to develop bioactive materials that accurately mimic one or more biophysical and biochemical properties of ECMs. We discuss the potential integration of these ECM-mimics into a range of physiological and pathological models, enhancing our understanding of cellular behavior and tissue organization. Lastly, we propose future research directions for ECM-mimics in the context of tissue engineering and organ-on-a-chip applications, offering potential advancements in therapeutic approaches and improved patient outcomes.

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