Steroid-receptor Coactivator Complexes in Thyroid Hormone-regulation of Xenopus Metamorphosis

Overview

Journal Vitam Horm

Specialties Endocrinology
Nutritional Sciences

Date 2023 Sep 17

PMID 37717995

Authors

Yuta Tanizaki

Lingyu Bao

Yun-Bo Shi

Affiliations

Soon will be listed here.

Abstract

Anuran metamorphosis is perhaps the most drastic developmental change regulated by thyroid hormone (T3) in vertebrate. It mimics the postembryonic development in mammals when many organs/tissues mature into adult forms and plasma T3 level peaks. T3 functions by regulating target gene transcription through T3 receptors (TRs), which can recruit corepressor or coactivator complexes to target genes in the absence or presence of T3, respectively. By using molecular and genetic approaches, we and others have investigated the role of corepressor or coactivator complexes in TR function during the development of two highly related anuran species, the pseudo-tetraploid Xenopus laevis and diploid Xenopus tropicalis. Here we will review some of these studies that demonstrate a critical role of coactivator complexes, particularly those containing steroid receptor coactivator (SRC) 3, in regulating metamorphic rate and ensuring the completion of metamorphosis.

Citing Articles

Functions and Mechanism of Thyroid Hormone Receptor Action During Amphibian Development.

Louis E, Fu L, Shi Y, Sachs L Endocrinology. 2024; 165(11).

PMID: 39397558 PMC: 11497603. DOI: 10.1210/endocr/bqae137.

Intestinal remodeling during Xenopus metamorphosis as a model for studying thyroid hormone signaling and adult organogenesis.

Shi Y, Fu L, Tanizaki Y Mol Cell Endocrinol. 2024; 586:112193.

PMID: 38401883 PMC: 10999354. DOI: 10.1016/j.mce.2024.112193.

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