Clinical Effect Analysis of Using Medical Glue Versus Conventional Suturing to Treat Dog Bite in Children's Maxillofacial Region After Negative Pressure Sealing Drainage: A Randomized Trial

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2023 Sep 15

PMID 37713853

Authors

Huang Lisong

Wang Lianfu

Yang Jinhong

Zhang Haibin

Affiliations

Soon will be listed here.

Abstract

Background: To compare the clinical effectiveness of applying medical glue versus conventional suturing after primary suturing and continuous vacuum sealing drainage (VSD) technology in the treatment of facial wounds caused by dog bites in children's maxillofacial region, with respect to operation time, wound infection rate, treatment effect, and patient satisfaction.

Methods: From May 2020 to July 2022, 68 children with a dog bite in the maxillofacial region were randomly divided into medical glue and conventional suturing groups. The patients in both groups were treated with conventional debridement, tetanus and/or rabies immunization, and antibiotic therapy. The medical glue group was treated with VSD after the first-stage of the loose suture of the wound. After 5 days, the suture was removed, and the wound was tightly bonded with medical glue again. The conventional suturing group was treated with VSD after the first-stage of loose suture of the wound. The primary outcomes were the operation time and satisfaction of the 2 groups, and the secondary outcomes was the wound infection rate.

Results: The operation time of the medical glue group was significantly lower than that of the conventional suturing group. However, there was no significant difference between the 2 groups in the wound infection rate. Still, the patient satisfaction was significantly better in the medical glue group than the conventional suturing group with statistically significant difference (P < .05).

Conclusion: In conclusion, applying medical glue after using negative pressure sealing drainage in treating maxillofacial dog bites can reduce surgeons work intensity, lessen children's pain, and improve the clinical treatment effect.

Citing Articles

Animal Bite Injuries to the Face: A Retrospective Evaluation of 111 Cases.

Maurer M, Schlipkoter C, Gottsauner M, Waiss W, Meier J, Fiedler M J Clin Med. 2023; 12(21).

PMID: 37959407 PMC: 10649818. DOI: 10.3390/jcm12216942.

References

Al-Mubarak L, Al-Haddab M . Cutaneous wound closure materials: an overview and update. J Cutan Aesthet Surg. 2014; 6(4):178-88. PMC: 3884880. DOI: 10.4103/0974-2077.123395. View

Sanders L, Nagatomi J . Clinical applications of surgical adhesives and sealants. Crit Rev Biomed Eng. 2015; 42(3-4):271-92. PMC: 7997729. DOI: 10.1615/critrevbiomedeng.2014011676. View

Talan D, Citron D, Abrahamian F, Moran G, Goldstein E . Bacteriologic analysis of infected dog and cat bites. Emergency Medicine Animal Bite Infection Study Group. N Engl J Med. 1999; 340(2):85-92. DOI: 10.1056/NEJM199901143400202. View

Bal-Ozturk A, Cecen B, Avci-Adali M, Topkaya S, Alarcin E, Yasayan G . Tissue Adhesives: From Research to Clinical Translation. Nano Today. 2021; 36. PMC: 7793024. DOI: 10.1016/j.nantod.2020.101049. View

Rui-Feng C, Li-Song H, Ji-Bo Z, Li-qiu W . Emergency treatment on facial laceration of dog bite wounds with immediate primary closure: a prospective randomized trial study. BMC Emerg Med. 2013; 13 Suppl 1:S2. PMC: 3701467. DOI: 10.1186/1471-227X-13-S1-S2. View

Dong R, Qin C, Qiu X, Yan X, Yu M, Cui L . In situ precision electrospinning as an effective delivery technique for cyanoacrylate medical glue with high efficiency and low toxicity. Nanoscale. 2015; 7(46):19468-75. DOI: 10.1039/c5nr05786h. View

Louis M, Meaike J, Chamata E, Hollier Jr L . Practical Considerations in Pediatric Surgery. Semin Plast Surg. 2016; 30(4):171-175. PMC: 5115919. DOI: 10.1055/s-0036-1593477. View

Banwell P, Musgrave M . Topical negative pressure therapy: mechanisms and indications. Int Wound J. 2006; 1(2):95-106. PMC: 7951556. DOI: 10.1111/j.1742-4801.2004.00031.x. View

Back D, Scheuermann-Poley C, Willy C . Recommendations on negative pressure wound therapy with instillation and antimicrobial solutions - when, where and how to use: what does the evidence show?. Int Wound J. 2013; 10 Suppl 1:32-42. PMC: 7950486. DOI: 10.1111/iwj.12183. View

10.

Davis K, Derlet R . Cyanoacrylate glues for wilderness and remote travel medical care. Wilderness Environ Med. 2012; 24(1):67-74. DOI: 10.1016/j.wem.2012.08.004. View

11.

Ghasemzadeh I, Namazi S . Review of bacterial and viral zoonotic infections transmitted by dogs. J Med Life. 2017; 8(Spec Iss 4):1-5. PMC: 5319273. View

12.

Bolton L . Evidence Corner: Which Dog Bite Wounds to Close and When?. Wounds. 2016; 28(4):142-4. View

13.

Shi P, Huang Y, Kou H, Wang T, Chen H . Risk Factors for Facial Appearance Dissatisfaction Among Orthognathic Patients: Comparing Patients to a Non-Surgical Sample. Front Psychol. 2020; 10:2775. PMC: 6917591. DOI: 10.3389/fpsyg.2019.02775. View

14.

Zempsky W, Zehrer C, Lyle C, Hedbloom E . Economic comparison of methods of wound closure: wound closure strips vs. sutures and wound adhesives. Int Wound J. 2006; 2(3):272-81. PMC: 7951558. DOI: 10.1111/j.1742-4801.2005.00130.x. View

15.

Nolff M, Fehr M, Bolling A, Dening R, Kramer S, Reese S . Negative pressure wound therapy, silver coated foam dressing and conventional bandages in open wound treatment in dogs. A retrospective comparison of 50 paired cases. Vet Comp Orthop Traumatol. 2014; 28(1):30-8. DOI: 10.3415/VCOT-14-05-0076. View

16.

Kang R, Li H, Lysdahl H, Le D, Chen M, Xie L . Cyanoacrylate medical glue application in intervertebral disc annulus defect repair: Mechanical and biocompatible evaluation. J Biomed Mater Res B Appl Biomater. 2015; 105(1):14-20. DOI: 10.1002/jbm.b.33524. View

17.

Sebesta M, Bishoff J . Octylcyanoacrylate skin closure in laparoscopy. JSLS. 2004; 8(1):9-14. PMC: 3015510. View

18.

Chhabra S, Chhabra N, Gaba S . Maxillofacial injuries due to animal bites. J Maxillofac Oral Surg. 2015; 14(2):142-53. PMC: 4444665. DOI: 10.1007/s12663-013-0593-5. View

19.

Elizabeth Murray G . Examining evidence on dog bite injuries and their management in children. Nurs Child Young People. 2017; 29(3):35-39. DOI: 10.7748/ncyp.2017.e859. View

20.

Quinn J, Drzewiecki A, Stiell I, Elmslie T . Appearance scales to measure cosmetic outcomes of healed lacerations. Am J Emerg Med. 1995; 13(2):229-31. DOI: 10.1016/0735-6757(95)90100-0. View