Salidroside Promotes Healthy Longevity by Interfering with HSP90 Activity

Overview

Journal Geroscience

Specialty Geriatrics

Date 2023 Sep 15

PMID 37713088

Authors

Jianfei Zhang

Zhiquan Li

Jiangbo Song

Lei Zhou

Xin Chen

Wen Ge

Tianyi Dong

Yuxin Luo

Ting Mao

Zheng Li

Duan Tan

Lene Juel Rasmussen

Vilhelm A Bohr

Xiaoling Tong

Fangyin Dai

Affiliations

Soon will be listed here.

Abstract

Aging is a risk factor for human health and quality of life. Screening and development of novel supplements and medications to combat aging and delay the incidence of age-related diseases are of great significance. In this study, salidroside (SA), a primary natural small molecule from Rhodiola rosea, was investigated regarding its effects on life and healthspan and the underlying molecular mechanism(s) of anti-aging and antioxidation. Our results showed that SA effectively prolonged lifespan and exhibited anti-aging and antioxidative properties. Computer-assisted methods, label-free interaction analysis, and in vitro assays showed that SA directly bound heat shock protein 90 (HSP90). Furthermore, SA significantly inhibited the ATPase activity of HSP90, affecting the interaction between HSP90 and its interacting proteins and the expression of downstream genes to regulate lifespan and the oxidative stress response. Our findings provided new insights into the pharmacological properties of SA across multiple species and its potential as an anti-aging drug.

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