Inhibition of PHD3 by Salidroside Promotes Neovascularization Through Cell-cell Communications Mediated by Muscle-secreted Angiogenic Factors

Overview

Journal Sci Rep

Specialty Science

Date 2017 Mar 8

PMID 28266625

Citations 22

Authors

Jing Zhang

Vivi Kasim

Yu-Dan Xie

Can Huang

Julita Sisjayawan

Agnes Dwi Ariyanti

Xue-Song Yan

Xiao-Yan Wu

Cai-Ping Liu

Li Yang

Makoto Miyagishi

Shou-Rong Wu

Affiliations

Soon will be listed here.

Abstract

Therapeutic angiogenesis has been considered as a potential strategy for treating peripheral artery diseases including hind-limb ischemia (HLI); however, no effective drug-based treatment is currently available. Here we showed that intramuscular administration of salidroside, an active compound of Chinese herb Rhodiola, could robustly enhance blood perfusion recovery by promoting neovascularization in HLI mice. We revealed that salidroside promoted skeletal muscle cell migration and paracrine function through inhibiting the transcriptional level of prolyl-hydroxylase domain 3 (PHD3) without affecting PHD1 and PHD2. Paracrine signals from salidroside-treated skeletal muscle cells enhanced endothelial and smooth muscle cells migration, while inhibition of FGF2/FGF2R and PDGF-BB/PDGFR-β pathways abolished this effect, as well as neovascularization in HLI mice. Furthermore, we elucidated that salidroside inhibition on PHD3 might occur through estrogen receptor alpha (ERα). Together, our findings highlights the potential application of salidroside as a novel pharmalogical inhibitor of ERα/PHD3 axis for therapeutic angiogenesis in HLI diseases.

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