Metformin-induced Activation of Ca Signaling Prevents Immune Infiltration/pathology in Sjogren's Syndrome-prone Mouse Models

Overview

Journal J Transl Autoimmun

Date 2023 Sep 15

PMID 37711153

Authors

Viviane Nascimento Da Conceicao

Yuyang Sun

Xiufang Chai

Julian L Ambrus

Bibhuti B Mishra

Brij B Singh

Affiliations

Soon will be listed here.

Abstract

Immune cell infiltration and glandular dysfunction are the hallmarks of autoimmune diseases such as primary Sjogren's syndrome (pSS), however, the mechanism(s) is unknown. Our data show that metformin-treatment induces the salivary glands of IL14α-transgenic mice (IL14α), which is a model for pSS. Mechanistically, we show that loss of in IL14α mice. Furthermore, the loss of Finally, restoration of metformin-induced inhibited the release of alarmins and prevented the activation of ER stress that was essential for immune cell infiltration. These results suggest that loss of metformin-mediated activation of signaling prevents ER stress, which inhibited the release of alarmins that induces immune cell infiltration leading to salivary gland dysfunction observed in pSS.

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