Current Status and Issues in Genomic Analysis Using EUS-FNA/FNB Specimens in Hepatobiliary-pancreatic Cancers

Overview

Journal J Gastroenterol

Specialty Gastroenterology

Date 2023 Sep 12

PMID 37698719

Authors

Yoshinori Ozono

Hiroshi Kawakami

Naomi Uchiyama

Hiroshi Hatada

Souichiro Ogawa

Affiliations

Soon will be listed here.

Abstract

Comprehensive genomic profiling based on next-generation sequencing has recently been used to provide precision medicine for various advanced cancers. Endoscopic ultrasound (EUS)-guided fine-needle aspiration (EUS-FNA) and EUS-guided fine-needle biopsy (EUS-FNB) play essential roles in the diagnosis of abdominal masses, mainly pancreatic cancers. In recent years, CGP analysis using EUS-FNA/FNB specimens for hepatobiliary-pancreatic cancers has increased; however, the success rate of CGP analysis is not clinically satisfactory, and many issues need to be resolved to improve the success rate of CGP analysis. In this article, we review the transition from EUS-FNA to FNB, compare each test, and discuss the current status and issues in genomic analysis of hepatobiliary-pancreatic cancers using EUS-FNA/FNB specimens.

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