Endoscopic Ultrasound-Guided Tissue Sampling for the Cytohistological Diagnosis of Focal Liver Lesions

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2024 Jun 19

PMID 38893681

Authors

Jose Larino-Noia

Andrea Jardi-Cuadrado

Juan Enrique Dominguez-Munoz

Yessica Dominguez-Novoa

Marco Galego

Alberto Rama

Daniel de la Iglesia-Garcia

Xurxo Martinez-Seara

Ihab Abdulkader-Nallib

Julio Iglesias-Garcia

Affiliations

Soon will be listed here.

Abstract

Background: Focal liver lesions (FLL) often require cytohistological evaluation. Endoscopic Ultrasound (EUS)-guided tissue acquisition (EUS-TA) is highly accurate in diagnosing pancreatic and gastrointestinal malignancies. The aim of our study was to evaluate the role of EUS-TA in the characterization of FLL.

Methods: A retrospective analysis of a prospective database of patients who underwent EUS-TA for the evaluation of FLL. Diagnostic yield, adverse events and factors associated with diagnostic yield were evaluated as endpoints. The effect of variables such as needle size, lesion size, rapid on-site evaluation (ROSE) and the use of cytological or histological needles were analyzed.

Results: A total of 114 cases were included (mean age 68.05 ± 11.35 years, 64 male). A correct diagnosis was made using EUS-TA in 100 of the 114 cases (diagnostic yield of 88%). The EUS-TA of additional extrahepatic lesions during the same EUS procedure increased the diagnostic yield to 94%. No adverse events were reported. Multivariate analysis did not identify any factor influencing the diagnostic yield.

Conclusions: EUS-TA is a highly accurate and safe technique for the differential diagnosis of FLL and could be considered as the primary approach in this setting.

Citing Articles

The outcomes of endoscopic ultrasound-guided tissue acquisition for small focal liver lesions measuring ≤2 cm.

Takano Y, Tamai N, Yamawaki M, Noda J, Azami T, Niiya F DEN Open. 2024; 5(1):e70031.

PMID: 39439546 PMC: 11494021. DOI: 10.1002/deo2.70031.

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