Control of Adipose Tissue Cellularity by the Terminal Complement Cascade

Overview

Journal Nat Rev Endocrinol

Specialty Endocrinology

Date 2023 Sep 11

PMID 37696916

Authors

Ilja L Kruglikov

Philipp E Scherer

Affiliations

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References

Kruglikov I, Shah M, Scherer P . Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral-bacterial interactions. Elife. 2020; 9. PMC: 7492082. DOI: 10.7554/eLife.61330. View

Mathieson P, Wurzner R, Oliveria D, LACHMANN P, PETERS D . Complement-mediated adipocyte lysis by nephritic factor sera. J Exp Med. 1993; 177(6):1827-31. PMC: 2191037. DOI: 10.1084/jem.177.6.1827. View

van Greevenbroek M, Ghosh S, van der Kallen C, Brouwers M, Schalkwijk C, Stehouwer C . Up-regulation of the complement system in subcutaneous adipocytes from nonobese, hypertriglyceridemic subjects is associated with adipocyte insulin resistance. J Clin Endocrinol Metab. 2012; 97(12):4742-52. PMC: 3513546. DOI: 10.1210/jc.2012-2539. View

Kaye S, Lokki A, Hanttu A, Nissila E, Heinonen S, Hakkarainen A . Upregulation of Early and Downregulation of Terminal Pathway Complement Genes in Subcutaneous Adipose Tissue and Adipocytes in Acquired Obesity. Front Immunol. 2017; 8:545. PMC: 5432622. DOI: 10.3389/fimmu.2017.00545. View

Corvillo F, Gonzalez-Sanchez L, Lopez-Lera A, Arjona E, Ceccarini G, Santini F . Complement Factor D (adipsin) Levels Are Elevated in Acquired Partial Lipodystrophy (Barraquer-Simons syndrome). Int J Mol Sci. 2021; 22(12). PMC: 8234012. DOI: 10.3390/ijms22126608. View