The Effects of Extract, and Their Joint Interventions on Glycolipid and Energy Metabolism in Obese Mice

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2023 Sep 11

PMID 37693249

Authors

Yuhan Xu

Xiuzhen Jia

Wei Zhang

Qiaoling Xie

Meizhen Zhu

Zifu Zhao

Jingyu Hao

Haoqiu Li

Jinrui Du

Yan Liu

Haotian Feng

Jian He

Hongwei Li

Affiliations

Soon will be listed here.

Abstract

Objectives: Obesity is often associated with glucolipid and/or energy metabolism disorders. extract (seaweed extract, SE) and extract (tea extract, TE) have been reported to promote positive metabolic effects through different mechanisms. We investigated the effects of SE and TE on metabolic homeostasis in diet-induced obese mice and discussed their functional characteristics.

Methods: Male C57BL/6J mice fed with high-fat diets for 8 weeks were established as obese models and subsequently divided into different intervention groups, followed by SE, TE, and their joint interventions for 10 weeks. Body weight and food intake were monitored. Fasting glucose and oral glucose tolerance tests were interspersed during the experiment. After the intervention, the effects on obesity control were assessed based on body composition, liver pathology section, blood lipids and glucose, respiratory exchange ratio (RER), energy expenditure (EE, EE, and EE), inflammatory factors, lipid anabolism enzymes, and gut flora of the obese mice.

Results: After continuous gavage intervention, the mice in the intervention groups exhibited lower body weight (lower ~4.93 g, vs. HFD 38.02 g), peri-testicular fat masses (lower ~0.61 g, vs. HFD 1.92 g), and perirenal fat masses (lower ~0.21 g, vs. HFD mice 0.70 g). All interventions prevented diet-induced increases in plasma levels of glucose, adiponectin, leptin, and the inflammatory factors IL-1β and TNF-α. The RER was modified by the interventions, while the rhythm of the RER was not. Blood lipids (total cholesterol, triglycerides, and LDL) decreased and were associated with lower lipid anabolism enzymes. In addition, the SE and TE interventions altered the structure and abundance of specific flora. Different interventions inhibited the growth of different genera positively associated with obesity (, etc.) and promoted the growth of and , thus affecting the chronic inflammatory state.

Conclusion: SE and TE both have synergistic effects on weight control and glucolipid metabolism regulation by improving insulin sensitivity and reducing lipid synthesis-related enzyme expression, whereas the combination of SE and TE (3:1) has a better effect on regulating energy metabolism and inhibiting chronic inflammation.

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