Crosstalk Between Glioblastoma and Tumor Microenvironment Drives Proneural-mesenchymal Transition Through Ligand-receptor Interactions

Overview

Journal Genes Dis

Date 2023 Sep 11

PMID 37692522

Authors

Yancheng Lai

Xiaole Lu

Yankai Liao

Pei Ouyang

Hai Wang

Xian Zhang

Guanglong Huang

Songtao Qi

Yaomin Li

Affiliations

Soon will be listed here.

Abstract

Glioblastoma (GBM) is the most common intrinsic and aggressive primary brain tumor in adults, with a median survival of approximately 15 months. GBM heterogeneity is considered responsible for the treatment resistance and unfavorable prognosis. Proneural-mesenchymal transition (PMT) represents GBM malignant progression and recurrence, which might be a breakthrough to understand GBM heterogeneity and overcome treatment resistance. PMT is a complicated process influenced by crosstalk between GBM and tumor microenvironment, depending on intricate ligand-receptor interactions. In this review, we summarize the autocrine and paracrine pathways in the GBM microenvironment and related ligand-receptor interactions inducing PMT. We also discuss the current therapies targeting the PMT-related autocrine and paracrine pathways. Together, this review offers a comprehensive understanding of the failure of GBM-targeted therapy and ideas for future tendencies of GBM treatment.

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