Decoding MA MRNA Methylation by Reader Proteins in Liver Diseases

Overview

Journal Genes Dis

Date 2023 Sep 11

PMID 37692496

Authors

Lijiao Sun

Xin Chen

Sai Zhu

Jianan Wang

Shaoxi Diao

Jinyu Liu

Jinjin Xu

Xiaofeng Li

Yingyin Sun

Cheng Huang

Xiaoming Meng

Xiongwen Lv

Jun Li

Affiliations

Soon will be listed here.

Abstract

N6-methyladenosine (mA) is a dynamic and reversible epigenetic regulation. As the most prevalent internal post-transcriptional modification in eukaryotic RNA, it participates in the regulation of gene expression through various mechanisms, such as mRNA splicing, nuclear export, localization, translation efficiency, mRNA stability, and structural transformation. The involvement of m6A in the regulation of gene expression depends on the specific recognition of m6A-modified RNA by reader proteins. In the pathogenesis and treatment of liver disease, studies have found that the expression levels of key genes that promote or inhibit the development of liver disease are regulated by mA modification, in which abnormal expression of reader proteins determines the fate of these gene transcripts. In this review, we introduce mA readers, summarize the recognition and regulatory mechanisms of mA readers on mRNA, and focus on the biological functions and mechanisms of mA readers in liver cancer, viral hepatitis, non-alcoholic fatty liver disease (NAFLD), hepatic fibrosis (HF), acute liver injury (ALI), and other liver diseases. This information is expected to be of high value to researchers deciphering the links between mA readers and human liver diseases.

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