Macrolide Esterases: Current Threats and Opportunities

Overview

Journal Trends Microbiol

Date 2023 Sep 9

PMID 37689489

Authors

Poonam Dhindwal

Iryna Myziuk

Antonio Ruzzini

Affiliations

Soon will be listed here.

Abstract

Antibiotics often contain ester bonds. The macrocyclic lactones of macrolides are pre-eminent examples in which ester bonds are essential to the form and function of antibiotics. Bacterial macrolide esterases that hydrolyze these macrocyclic lactones to confer antimicrobial resistance (AMR) are the topic of this forum. We provide insight into their role in agricultural systems and discuss their emergence and their potential extensibility to bioremediation efforts.

Citing Articles

Identification, characterization, and distribution of novel amidase gene in sphingomonads conferring resistance to amphenicol antibiotics.

Qian Y, Lai L, Cheng M, Fang H, Fan D, Zylstra G Appl Environ Microbiol. 2024; 90(11):e0151224.

PMID: 39431819 PMC: 11577797. DOI: 10.1128/aem.01512-24.

The global distribution of the macrolide esterase EstX from the alpha/beta hydrolase superfamily.

Lin J, Lv H, Wang T, Tao H, Zhong Y, Zhou Y Commun Biol. 2024; 7(1):781.

PMID: 38944651 PMC: 11214618. DOI: 10.1038/s42003-024-06473-2.

Exploring the Thermal-Oxidative Stability of Azithromycin Using a Thermoactivated Sensor Based on Cerium Molybdate and Multi-Walled Carbon Nanotubes.

Costa H, Santos A, Teixeira Y, Silva M, Feitosa V, Morais S Nanomaterials (Basel). 2024; 14(11).

PMID: 38869524 PMC: 11173558. DOI: 10.3390/nano14110899.

Comparison of (X4)-containing contigs assembled from metagenomic sequencing data with plasmid sequences of isolates from a cohort of healthy subjects.

Ding Y, Er S, Tan A, Gounot J, Saw W, Tan L Microbiol Spectr. 2024; 12(4):e0396923.

PMID: 38441466 PMC: 10986321. DOI: 10.1128/spectrum.03969-23.

Antibiotic Potentiation as a Promising Strategy to Combat Macrolide Resistance in Bacterial Pathogens.

Paul D, Chawla M, Ahrodia T, Narendrakumar L, Das B Antibiotics (Basel). 2023; 12(12).

PMID: 38136749 PMC: 10740890. DOI: 10.3390/antibiotics12121715.