Advances in Biodegradable Polymers and Biomaterials for Medical Applications-A Review

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Sep 9

PMID 37687042

Authors

Malgorzata Oleksy

Klaudia Dynarowicz

David Aebisher

Affiliations

Soon will be listed here.

Abstract

The introduction of new materials for the production of various types of constructs that can connect directly to tissues has enabled the development of such fields of science as medicine, tissue, and regenerative engineering. The implementation of these types of materials, called biomaterials, has contributed to a significant improvement in the quality of human life in terms of health. This is due to the constantly growing availability of new implants, prostheses, tools, and surgical equipment, which, thanks to their specific features such as biocompatibility, appropriate mechanical properties, ease of sterilization, and high porosity, ensure an improvement of living. Biodegradation ensures, among other things, the ideal rate of development for regenerated tissue. Current tissue engineering and regenerative medicine strategies aim to restore the function of damaged tissues. The current gold standard is autografts (using the patient's tissue to accelerate healing), but limitations such as limited procurement of certain tissues, long operative time, and donor site morbidity have warranted the search for alternative options. The use of biomaterials for this purpose is an attractive option and the number of biomaterials being developed and tested is growing rapidly.

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References

Vacanti N, Cheng H, Hill P, Guerreiro J, Dang T, Ma M . Localized delivery of dexamethasone from electrospun fibers reduces the foreign body response. Biomacromolecules. 2012; 13(10):3031-8. PMC: 3466020. DOI: 10.1021/bm300520u. View

Malafaya P, Silva G, Reis R . Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. Adv Drug Deliv Rev. 2007; 59(4-5):207-33. DOI: 10.1016/j.addr.2007.03.012. View

HANKER J, Giammara B . Biomaterials and biomedical devices. Science. 1988; 242(4880):885-92. DOI: 10.1126/science.3055300. View

Vishwakarma A, Bhise N, Evangelista M, Rouwkema J, Dokmeci M, Ghaemmaghami A . Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response. Trends Biotechnol. 2016; 34(6):470-482. DOI: 10.1016/j.tibtech.2016.03.009. View

Zheng J, Kang J, Sun C, Yang C, Wang L, Li D . Effects of printing path and material components on mechanical properties of 3D-printed polyether-ether-ketone/hydroxyapatite composites. J Mech Behav Biomed Mater. 2021; 118:104475. DOI: 10.1016/j.jmbbm.2021.104475. View

Li X, Xie J, Yuan X, Xia Y . Coating electrospun poly(epsilon-caprolactone) fibers with gelatin and calcium phosphate and their use as biomimetic scaffolds for bone tissue engineering. Langmuir. 2008; 24(24):14145-50. DOI: 10.1021/la802984a. View

Murphy C, OBrien F, Little D, Schindeler A . Cell-scaffold interactions in the bone tissue engineering triad. Eur Cell Mater. 2013; 26:120-32. DOI: 10.22203/ecm.v026a09. View

Li Z, Tan B . Towards the development of polycaprolactone based amphiphilic block copolymers: molecular design, self-assembly and biomedical applications. Mater Sci Eng C Mater Biol Appl. 2014; 45:620-34. DOI: 10.1016/j.msec.2014.06.003. View

Sunil B, Kumar T, Chakkingal U, Nandakumar V, Doble M . Friction stir processing of magnesium-nanohydroxyapatite composites with controlled in vitro degradation behavior. Mater Sci Eng C Mater Biol Appl. 2014; 39:315-24. DOI: 10.1016/j.msec.2014.03.004. View

10.

Fan J, Cheng Y, Sun M . Functionalized Gold Nanoparticles: Synthesis, Properties and Biomedical Applications. Chem Rec. 2020; 20(12):1474-1504. DOI: 10.1002/tcr.202000087. View

11.

Rahmati M, Pennisi C, Budd E, Mobasheri A, Mozafari M . Biomaterials for Regenerative Medicine: Historical Perspectives and Current Trends. Adv Exp Med Biol. 2018; 1119:1-19. DOI: 10.1007/5584_2018_278. View

12.

Jiang A, Patel R, Padhan B, Palimkar S, Galgali P, Adhikari A . Chitosan Based Biodegradable Composite for Antibacterial Food Packaging Application. Polymers (Basel). 2023; 15(10). PMC: 10223533. DOI: 10.3390/polym15102235. View

13.

Salthouse D, Novakovic K, Hilkens C, Marina Ferreira A . Interplay between biomaterials and the immune system: Challenges and opportunities in regenerative medicine. Acta Biomater. 2022; 155:1-18. DOI: 10.1016/j.actbio.2022.11.003. View

14.

Coburn J, Gibson M, Monagle S, Patterson Z, Elisseeff J . Bioinspired nanofibers support chondrogenesis for articular cartilage repair. Proc Natl Acad Sci U S A. 2012; 109(25):10012-7. PMC: 3382486. DOI: 10.1073/pnas.1121605109. View

15.

Lee S, Miyajima T, Sugawara-Narutaki A, Kato K, Nagata F . Development of paclitaxel-loaded poly(lactic acid)/hydroxyapatite core-shell nanoparticles as a stimuli-responsive drug delivery system. R Soc Open Sci. 2021; 8(3):202030. PMC: 8074949. DOI: 10.1098/rsos.202030. View

16.

Lutolf M, Hubbell J . Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol. 2005; 23(1):47-55. DOI: 10.1038/nbt1055. View

17.

AlShahrani S, AlAbbas M, Garcia I, AlGhannam M, AlRuwaili M, Collares F . The Antibacterial Effects of Resin-Based Dental Sealants: A Systematic Review of In Vitro Studies. Materials (Basel). 2021; 14(2). PMC: 7830019. DOI: 10.3390/ma14020413. View

18.

Huang Z, Wan Y, Zhu X, Zhang P, Yang Z, Yao F . Simultaneous engineering of nanofillers and patterned surface macropores of graphene/hydroxyapatite/polyetheretherketone ternary composites for potential bone implants. Mater Sci Eng C Mater Biol Appl. 2021; 123:111967. DOI: 10.1016/j.msec.2021.111967. View

19.

Edalat F, Sheu I, Manoucheri S, Khademhosseini A . Material strategies for creating artificial cell-instructive niches. Curr Opin Biotechnol. 2012; 23(5):820-5. PMC: 3534967. DOI: 10.1016/j.copbio.2012.05.007. View

20.

Bat E, van Kooten T, Feijen J, Grijpma D . Resorbable elastomeric networks prepared by photocrosslinking of high-molecular-weight poly(trimethylene carbonate) with photoinitiators and poly(trimethylene carbonate) macromers as crosslinking aids. Acta Biomater. 2011; 7(5):1939-48. DOI: 10.1016/j.actbio.2011.01.010. View