Corruptive Reprograming of Macrophages into Tumor-Associated Macrophages: The Transcriptional, Epigenetic and Metabolic Basis

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2023 Sep 9

PMID 37686567

Authors

Aamir Ahmad

Affiliations

Soon will be listed here.

Abstract

The tumor microenvironment (TME) is an important place with regard to the growth and sustenance of tumor cells [...].

References

Chen F, Chen J, Yang L, Liu J, Zhang X, Zhang Y . Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells. Nat Cell Biol. 2019; 21(4):498-510. DOI: 10.1038/s41556-019-0299-0. View

Guerriero J . Macrophages: Their Untold Story in T Cell Activation and Function. Int Rev Cell Mol Biol. 2019; 342:73-93. DOI: 10.1016/bs.ircmb.2018.07.001. View

Ahmad A . Non-coding RNAs: A tale of junk turning into treasure. Noncoding RNA Res. 2018; 1(1):1-2. PMC: 6096404. DOI: 10.1016/j.ncrna.2016.12.001. View

Van den Bossche J, ONeill L, Menon D . Macrophage Immunometabolism: Where Are We (Going)?. Trends Immunol. 2017; 38(6):395-406. DOI: 10.1016/j.it.2017.03.001. View

Zhang J, Tian W, Wang F, Liu J, Huang J, Duangmano S . Advancements in understanding the role of microRnas in regulating macrophage polarization during acute lung injury. Cell Cycle. 2023; 22(14-16):1694-1712. PMC: 10446815. DOI: 10.1080/15384101.2023.2230018. View

Lin Y, Xu J, Lan H . Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications. J Hematol Oncol. 2019; 12(1):76. PMC: 6626377. DOI: 10.1186/s13045-019-0760-3. View

Ahmad A . Epigenetic regulation of immunosuppressive tumor-associated macrophages through dysregulated microRNAs. Semin Cell Dev Biol. 2021; 124:26-33. DOI: 10.1016/j.semcdb.2021.09.001. View

Audia J, Campbell R . Histone Modifications and Cancer. Cold Spring Harb Perspect Biol. 2016; 8(4):a019521. PMC: 4817802. DOI: 10.1101/cshperspect.a019521. View

Boulding T, McCuaig R, Tan A, Hardy K, Wu F, Dunn J . LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer. Sci Rep. 2018; 8(1):73. PMC: 5758711. DOI: 10.1038/s41598-017-17913-x. View

10.

Ke X, Chen C, Song Y, Cai Q, Li J, Tang Y . Hypoxia modifies the polarization of macrophages and their inflammatory microenvironment, and inhibits malignant behavior in cancer cells. Oncol Lett. 2019; 18(6):5871-5878. PMC: 6865149. DOI: 10.3892/ol.2019.10956. View

11.

Wu H, Han Y, Rodriguez Sillke Y, Deng H, Siddiqui S, Treese C . Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages. EMBO Mol Med. 2019; 11(11):e10698. PMC: 6835560. DOI: 10.15252/emmm.201910698. View

12.

Rodriguez-Ubreva J, Garcia-Gomez A, Ballestar E . Epigenetic mechanisms of myeloid differentiation in the tumor microenvironment. Curr Opin Pharmacol. 2017; 35:20-29. DOI: 10.1016/j.coph.2017.04.008. View

13.

Zhang C, Yang M, Ericsson A . Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms. Front Immunol. 2021; 12:620510. PMC: 7982479. DOI: 10.3389/fimmu.2021.620510. View

14.

Larionova I, Kazakova E, Patysheva M, Kzhyshkowska J . Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages. Cancers (Basel). 2020; 12(6). PMC: 7352439. DOI: 10.3390/cancers12061411. View

15.

Duan Z, Luo Y . Targeting macrophages in cancer immunotherapy. Signal Transduct Target Ther. 2021; 6(1):127. PMC: 7994399. DOI: 10.1038/s41392-021-00506-6. View

16.

Jeong H, Kim S, Hong B, Lee C, Kim Y, Bok S . Tumor-Associated Macrophages Enhance Tumor Hypoxia and Aerobic Glycolysis. Cancer Res. 2019; 79(4):795-806. DOI: 10.1158/0008-5472.CAN-18-2545. View

17.

Ahmad A . Guest Edited Collection: Epigenetics within the tumor microenvironment. Sci Rep. 2022; 12(1):15089. PMC: 9445032. DOI: 10.1038/s41598-022-19042-6. View

18.

Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung A . Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nat Immunol. 2012; 13(7):642-50. PMC: 3513378. DOI: 10.1038/ni.2304. View

19.

Rasool M, Malik A, Zahid S, Ashraf M, Qazi M, Asif M . Non-coding RNAs in cancer diagnosis and therapy. Noncoding RNA Res. 2018; 1(1):69-76. PMC: 6096421. DOI: 10.1016/j.ncrna.2016.11.001. View

20.

Yu M, Jia H, Zhang J, Ran G, Liu Y, Yang X . Exosomal miRNAs-mediated macrophage polarization and its potential clinical application. Int Immunopharmacol. 2023; 117:109905. DOI: 10.1016/j.intimp.2023.109905. View