» Articles » PMID: 28551408

Epigenetic Mechanisms of Myeloid Differentiation in the Tumor Microenvironment

Overview
Specialty Pharmacology
Date 2017 May 29
PMID 28551408
Citations 7
Authors
Affiliations
Soon will be listed here.
Abstract

Myeloid cells are extremely plastic as they respond and terminally differentiate into a plethora of functional types, in the blood or tissues, in response to a variety of growth factors, cytokines and pathogenic molecules. This plasticity is also manifested by the subversion of normal differentiation into the aberrant generation of a variety of tolerogenic myeloid cells in the tumoral microenvironment, where a variety of factors are released. Epigenetic mechanisms are in great part responsible for the plasticity of myeloid cells both under physiological and tumoral conditions. The development of compounds that inhibit epigenetic enzymes provides novel therapeutic opportunities to intercept the crosstalk between cancer cells and host myeloid cells. Here, we summarize our current knowledge on the myeloid cell types generated in the cancer environment, the factors and epigenetic enzymes participating in these processes and propose a number of potential targets for future pharmacological use.

Citing Articles

Corruptive Reprograming of Macrophages into Tumor-Associated Macrophages: The Transcriptional, Epigenetic and Metabolic Basis.

Ahmad A Cancers (Basel). 2023; 15(17).

PMID: 37686567 PMC: 10487138. DOI: 10.3390/cancers15174291.


Targeting Epigenetic Mechanisms: A Boon for Cancer Immunotherapy.

Parab A, Bhatt L, Omri A Biomedicines. 2023; 11(1).

PMID: 36672677 PMC: 9855697. DOI: 10.3390/biomedicines11010169.


Epigenetic Regulation of Immunotherapy Response in Triple-Negative Breast Cancer.

Llinas-Arias P, Iniguez-Munoz S, McCann K, Voorwerk L, Orozco J, Ensenyat-Mendez M Cancers (Basel). 2021; 13(16).

PMID: 34439290 PMC: 8394958. DOI: 10.3390/cancers13164139.


Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages.

Larionova I, Kazakova E, Patysheva M, Kzhyshkowska J Cancers (Basel). 2020; 12(6).

PMID: 32486098 PMC: 7352439. DOI: 10.3390/cancers12061411.


Inflammatory Responses during Tumour Initiation: From Zebrafish Transgenic Models of Cancer to Evidence from Mouse and Man.

Elliot A, Myllymaki H, Feng Y Cells. 2020; 9(4).

PMID: 32325966 PMC: 7226149. DOI: 10.3390/cells9041018.