Assessment of Impaired Cerebral Autoregulation and Its Correlation with Neurological Outcome in Aneurysmal Subarachnoid Hemorrhage: A Prospective and Observational Study

Overview

Journal Surg Neurol Int

Specialty Neurology

Date 2023 Sep 8

PMID 37680917

Authors

Ketan Kataria

Nidhi Bidyut Panda

Ankur Luthra

Shalvi Mahajan

Hemant Bhagat

Rajeev Chauhan

Shiv Soni

Kiran Jangra

Narender Kaloria

Shamik Paul

Summit Bloria

Shailesh Gupta

Rajesh Chhabra

Affiliations

Soon will be listed here.

Abstract

Background: Cerebral autoregulation (CA) is crucial for the maintenance of cerebral homeostasis. It can be assessed by measuring transient hyperemic response ratio (THRR) using transcranial Doppler (TCD). We aimed at assessing the incidence of impaired CA (ICA) and its correlation with the neurological outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH).

Methods: One hundred consecutive patients with aSAH scheduled for aneurysmal clipping were enrolled in this prospective and observational study. Preoperative and consecutive 5-day postoperative THRR measurements were taken. Primary objective of the study was to detect the incidence of ICA and its correlation with vasospasm (VS) postclipping, and neurological outcome at discharge and 1, 3, and 12 months was secondary objectives.

Results: ICA (THRR < 1.09) was observed in 69 patients preoperatively, 74 patients on the 1 and 2 postoperative day, 76 patients on 3 postoperative day, and 78 patients on 4 and 5 postoperative day. Significant VS was seen in 13.4% and 61.5% of patients with intact THRR and deranged THRR, respectively ( < 0.000). Out of 78 patients who had ICA, 42 patients (53.8%) at discharge, 60 patients (76.9%) at 1 month, 54 patients (69.2%) at 3 month, and 55 patients (70.5%) at 12 months had unfavorable neurological outcome significantly more than those with preserved CA.

Conclusion: Incidence of ICA assessed in aSAH patients varies from 69% to 78% in the perioperative period. The deranged CA was associated with significantly poor neurological outcome. Therefore, CA assessment using TCD-based THRR provides a simple, noninvasive bedside approach for predicting neurological outcome in aSAH.

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