Regulation of the Renin-angiotensin-aldosterone System by Cyclic Nucleotides and Phosphodiesterases

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2023 Sep 7

PMID 37674612

Authors

Stepan Gambaryan

Sanika Mohagaonkar

Viacheslav O Nikolaev

Affiliations

Soon will be listed here.

Abstract

The renin-angiotensin-aldosterone system (RAAS) is one of the key players in the regulation of blood volume and blood pressure. Dysfunction of this system is connected with cardiovascular and renal diseases. Regulation of RAAS is under the control of multiple intracellular mechanisms. Cyclic nucleotides and phosphodiesterases are the major regulators of this system since they control expression and activity of renin and aldosterone. In this review, we summarize known mechanisms by which cyclic nucleotides and phosphodiesterases regulate renin gene expression, secretion of renin granules from juxtaglomerular cells and aldosterone production from cells of adrenal gland. We also discuss several open questions which deserve future attention.

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References

Conti M, Beavo J . Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu Rev Biochem. 2007; 76:481-511. DOI: 10.1146/annurev.biochem.76.060305.150444. View

Peterson J, Moran F, Conley A, Bird I . Zonal expression of endothelial nitric oxide synthase in sheep and rhesus adrenal cortex. Endocrinology. 2001; 142(12):5351-63. DOI: 10.1210/endo.142.12.8537. View

Woodcock E, Johnston C . Inhibition of adenylate cyclase in rat adrenal glomerulosa cells by angiotensin II. Endocrinology. 1984; 115(1):337-41. DOI: 10.1210/endo-115-1-337. View

Clark B, Pezzi V, Stocco D, Rainey W . The steroidogenic acute regulatory protein is induced by angiotensin II and K+ in H295R adrenocortical cells. Mol Cell Endocrinol. 1995; 115(2):215-19. DOI: 10.1016/0303-7207(95)03683-0. View

Zaccolo M . Spatial control of cAMP signalling in health and disease. Curr Opin Pharmacol. 2011; 11(6):649-55. PMC: 4126235. DOI: 10.1016/j.coph.2011.09.014. View

Duan H, Jefcoate C . The predominant cAMP-stimulated 3 x 5 kb StAR mRNA contains specific sequence elements in the extended 3'UTR that confer high basal instability. J Mol Endocrinol. 2007; 38(1-2):159-79. DOI: 10.1677/jme.1.02153. View

Horvath A, Boikos S, Giatzakis C, Robinson-White A, Groussin L, Griffin K . A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia. Nat Genet. 2006; 38(7):794-800. DOI: 10.1038/ng1809. View

Kurtz A . Renin release: sites, mechanisms, and control. Annu Rev Physiol. 2010; 73:377-99. DOI: 10.1146/annurev-physiol-012110-142238. View

Zaccolo M, Movsesian M . cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology. Circ Res. 2007; 100(11):1569-78. DOI: 10.1161/CIRCRESAHA.106.144501. View

10.

Arakane F, King S, Du Y, Kallen C, Walsh L, Watari H . Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity. J Biol Chem. 1998; 272(51):32656-62. DOI: 10.1074/jbc.272.51.32656. View

11.

Bell J, Tait J, TAIT S, Barnes G, Brown B . Lack of effect of angiotensin on levels of cyclic AMP in isolated adrenal zona glomerulosa cells from the rat. J Endocrinol. 1981; 91(1):145-54. DOI: 10.1677/joe.0.0910145. View

12.

Spat A, Hunyady L, Szanda G . Signaling Interactions in the Adrenal Cortex. Front Endocrinol (Lausanne). 2016; 7:17. PMC: 4770035. DOI: 10.3389/fendo.2016.00017. View

13.

Perera R, Nikolaev V . Compartmentation of cAMP signalling in cardiomyocytes in health and disease. Acta Physiol (Oxf). 2013; 207(4):650-62. DOI: 10.1111/apha.12077. View

14.

Abdellatif A, Fernandes-Rosa F, Boulkroun S, Zennaro M . Vascular and hormonal interactions in the adrenal gland. Front Endocrinol (Lausanne). 2022; 13:995228. PMC: 9731668. DOI: 10.3389/fendo.2022.995228. View

15.

Sayago C, BEIERWALTES W . Nitric oxide synthase and cGMP-mediated stimulation of renin secretion. Am J Physiol Regul Integr Comp Physiol. 2001; 281(4):R1146-51. DOI: 10.1152/ajpregu.2001.281.4.R1146. View

16.

Kraemer F, Shen W . Hormone-sensitive lipase: control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysis. J Lipid Res. 2002; 43(10):1585-94. DOI: 10.1194/jlr.r200009-jlr200. View

17.

Grunberger C, Obermayer B, Klar J, Kurtz A, Schweda F . The calcium paradoxon of renin release: calcium suppresses renin exocytosis by inhibition of calcium-dependent adenylate cyclases AC5 and AC6. Circ Res. 2006; 99(11):1197-206. DOI: 10.1161/01.RES.0000251057.35537.d3. View

18.

Burnay M, Vallotton M, Capponi A, Rossier M . Angiotensin II potentiates adrenocorticotrophic hormone-induced cAMP formation in bovine adrenal glomerulosa cells through a capacitative calcium influx. Biochem J. 1998; 330 ( Pt 1):21-7. PMC: 1219102. DOI: 10.1042/bj3300021. View

19.

Bos J . Epac: a new cAMP target and new avenues in cAMP research. Nat Rev Mol Cell Biol. 2003; 4(9):733-8. DOI: 10.1038/nrm1197. View

20.

Ortiz-Capisano M, Ortiz P, Harding P, Garvin J, Beierwaltes W . Adenylyl cyclase isoform v mediates renin release from juxtaglomerular cells. Hypertension. 2006; 49(3):618-24. DOI: 10.1161/01.HYP.0000255172.84842.d2. View