Modulatory Role of Vitamins A, B3, C, D, and E on Skin Health, Immunity, Microbiome, and Diseases

Overview

Journal Pharmacol Rep

Specialty Pharmacology

Date 2023 Sep 6

PMID 37673852

Authors

Mahika Joshi

Priyanka Hiremath

Jeena John

Niraja Ranadive

Krishnadas Nandakumar

Jayesh Mudgal

Affiliations

Soon will be listed here.

Abstract

Disruption of the skin barrier and immunity has been associated with several skin diseases, namely atopic dermatitis (AD), psoriasis, and acne. Resident and non-resident immune cells and the barrier system of the skin are integral to innate immunity. Recent advances in understanding skin microbiota have opened the scope of further understanding the various communications between these microbiota and skin immune cells. Vitamins, being one of the important micronutrients, have been reported to exert antioxidant, anti-inflammatory, and anti-microbial effects. The immunomodulatory action of vitamins can halt the progression of skin diseases, and thus, understanding the immuno-pharmacology of these vitamins, especially for skin diseases can pave the way for their therapeutic potential. At the same time, molecular and cellular markers modulated with these vitamins and their derivatives need to be explored. The present review is focused on significant vitamins (vitamins A, B3, C, D, and E) consumed as nutritional supplements to discuss the outcomes and scope of studies related to skin immunity, health, and diseases.

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References

Del Prado G, Terriza A, Ortiz-Perez A, Molina-Manso D, Mahillo I, Yubero F . DLC coatings for UHMWPE: relationship between bacterial adherence and surface properties. J Biomed Mater Res A. 2012; 100(10):2813-20. DOI: 10.1002/jbm.a.34220. View

Reygagne P, Bastien P, Couavoux M, Philippe D, Renouf M, Castiel-Higounenc I . The positive benefit of Lactobacillus paracasei NCC2461 ST11 in healthy volunteers with moderate to severe dandruff. Benef Microbes. 2017; 8(5):671-680. DOI: 10.3920/BM2016.0144. View

Antal A, Dombrowski Y, Koglin S, Ruzicka T, Schauber J . Impact of vitamin D3 on cutaneous immunity and antimicrobial peptide expression. Dermatoendocrinol. 2011; 3(1):18-22. PMC: 3051848. DOI: 10.4161/derm.3.1.14616. View

Steiling H, Longet K, Moodycliffe A, Mansourian R, Bertschy E, Smola H . Sodium-dependent vitamin C transporter isoforms in skin: Distribution, kinetics, and effect of UVB-induced oxidative stress. Free Radic Biol Med. 2007; 43(5):752-62. DOI: 10.1016/j.freeradbiomed.2007.05.001. View

SHALITA A, Smith J, Parish L, Sofman M, Chalker D . Topical nicotinamide compared with clindamycin gel in the treatment of inflammatory acne vulgaris. Int J Dermatol. 1995; 34(6):434-7. DOI: 10.1111/j.1365-4362.1995.tb04449.x. View

Pallast E, Schouten E, de Waart F, Fonk H, Doekes G, von Blomberg B . Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons. Am J Clin Nutr. 1999; 69(6):1273-81. DOI: 10.1093/ajcn/69.6.1273. View

Shindo Y, Witt E, Han D, Epstein W, Packer L . Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin. J Invest Dermatol. 1994; 102(1):122-4. DOI: 10.1111/1523-1747.ep12371744. View

Song H, Yoo Y, Hwang J, Na Y, Kim H . Faecalibacterium prausnitzii subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis. J Allergy Clin Immunol. 2015; 137(3):852-60. DOI: 10.1016/j.jaci.2015.08.021. View

Byrd A, Belkaid Y, Segre J . The human skin microbiome. Nat Rev Microbiol. 2018; 16(3):143-155. DOI: 10.1038/nrmicro.2017.157. View

10.

Thiele J, Ekanayake-Mudiyanselage S . Vitamin E in human skin: organ-specific physiology and considerations for its use in dermatology. Mol Aspects Med. 2007; 28(5-6):646-67. DOI: 10.1016/j.mam.2007.06.001. View

11.

Young A, Claveau J, Rossi A . Ultraviolet radiation and the skin: Photobiology and sunscreen photoprotection. J Am Acad Dermatol. 2017; 76(3S1):S100-S109. DOI: 10.1016/j.jaad.2016.09.038. View

12.

Castanedo-Cazares J, Larraga-Pinones G, Ehnis-Perez A, Fuentes-Ahumada C, Oros-Ovalle C, Smoller B . Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study. Clin Cosmet Investig Dermatol. 2013; 6:29-36. PMC: 3552481. DOI: 10.2147/CCID.S39246. View

13.

Harvima I, Nilsson G, Suttle M, Naukkarinen A . Is there a role for mast cells in psoriasis?. Arch Dermatol Res. 2008; 300(9):461-78. DOI: 10.1007/s00403-008-0874-x. View

14.

Wadhwa B, Relhan V, Goel K, Kochhar A, Garg V . Vitamin D and skin diseases: A review. Indian J Dermatol Venereol Leprol. 2015; 81(4):344-55. DOI: 10.4103/0378-6323.159928. View

15.

Garza-Davila V, Valdespino-Valdes J, Ramos A, Gonzalez-Martinez G, Herz-Ruelas M, Gomez-Flores M . Combination of NB-UVB phototherapy and oral vitamin D supplementation in patients with generalized vitiligo: A randomized, triple-blind, placebo-controlled clinical trial. J Eur Acad Dermatol Venereol. 2023; 37(12):e1423-e1425. DOI: 10.1111/jdv.19347. View

16.

Albanesi C, Madonna S, Gisondi P, Girolomoni G . The Interplay Between Keratinocytes and Immune Cells in the Pathogenesis of Psoriasis. Front Immunol. 2018; 9:1549. PMC: 6043636. DOI: 10.3389/fimmu.2018.01549. View

17.

Zhang Y, Leung D, Richers B, Liu Y, Remigio L, Riches D . Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol. 2012; 188(5):2127-35. PMC: 3368346. DOI: 10.4049/jimmunol.1102412. View

18.

Ozuguz P, Kacar S, Ekiz O, Takci Z, Balta I, Kalkan G . Evaluation of serum vitamins A and E and zinc levels according to the severity of acne vulgaris. Cutan Ocul Toxicol. 2013; 33(2):99-102. DOI: 10.3109/15569527.2013.808656. View

19.

Lee S, Ahn K, Paik H, Chung S . Serum immunoglobulin E (IgE) levels and dietary intake of Korean infants and young children with atopic dermatitis. Nutr Res Pract. 2012; 6(5):429-35. PMC: 3506874. DOI: 10.4162/nrp.2012.6.5.429. View

20.

Salem H, Kharshoum R, Awad S, Ahmed Mostafa M, Abou-Taleb H . Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study. Int J Nanomedicine. 2021; 16:4251-4276. PMC: 8239256. DOI: 10.2147/IJN.S301597. View