Differences Between Migrasome, a 'new Organelle', and Exosome

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2023 Sep 4

PMID 37665060

Authors

Xuebing Xu

Tong Wu

Renjie Lin

Shengze Zhu

Jie Ji

Dandan Jin

Mengxiang Huang

Wenjie Zheng

Wenkai Ni

Feng Jiang

Shihai Xuan

Mingbing Xiao

Affiliations

Soon will be listed here.

Abstract

The migrasome is a new organelle discovered by Professor Yu Li in 2015. When cells migrate, the membranous organelles that appear at the end of the retraction fibres are migrasomes. With the migration of cells, the retraction fibres which connect migrasomes and cells finally break. The migrasomes detach from the cell and are released into the extracellular space or directly absorbed by the recipient cell. The cytoplasmic contents are first transported to the migrasome and then released from the cell through the migrasome. This release mechanism, which depends on cell migration, is named 'migracytosis'. The main components of the migrasome are extracellular vesicles after they leave the cell, which are easy to remind people of the current hot topic of exosomes. Exosomes are extracellular vesicles wrapped by the lipid bimolecular layer. With extensive research, exosomes have solved many disease problems. This review summarizes the differences between migrasomes and exosomes in size, composition, property and function, extraction method and regulation mechanism for generation and release. At the same time, it also prospects for the current hotspot of migrasomes, hoping to provide literature support for further research on the generation and release mechanism of migrasomes and their clinical application in the future.

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