Seroconversion of Hepatitis B Vaccine Among Patients from Outpatient Clinic in Georgia

Overview

Journal Vaccine X

Date 2023 Sep 4

PMID 37663048

Authors

Giorgi Kanchelashvili

George Kamkamidze

Meri Davitadze

Nino Bzishvili

Tinatin Abzianidze

Lasha Gulbiani

Maia Butsashvili

Affiliations

Soon will be listed here.

Abstract

Introduction: Hepatitis B virus (HBV) is a serious global health challenge with vaccination being the most effective preventive measure. However, several risk-factors may impact HBV vaccine immunogenicity. We aimed to evaluate the immunogenicity of the HBV vaccine.

Methods: Participants' socio-demographic data were obtained from medical records. Anti-HBs testing was performed. Descriptive and bivariate analyses were performed.

Results: Among 431 participants, 62.2 % (n = 268) were males. In all, 43.2 % (n = 186) had normal weight, 24.8 % (n = 107) were overweight, and 17.6 % (n = 76) had obesity. Seroconversion after 3-dose HBV vaccination was 74.7 %. Participants with normal weight had higher seroprevalence (n = 156/186, 83.9 %), compared with those with overweight (n = 72/107, 67.3 %) or obesity (n = 48/76, 63.2 %) (Normal weight vs overweight: aOR = 2.44, 95 % CI: 1.38-4.32 and normal weight vs obesity: aOR = 2.97, 95 % CI:1.61-5.47).

Conclusion: BMI is an independent factor impairing the vaccine response. These findings urge for more tailored vaccination strategies with focus on higher risk populations.

References

Kasradze A, Shadaker S, Kuchuloria T, Gamkrelidze A, Nasrullah M, Gvinjilia L . The burden and epidemiology of hepatitis B and hepatitis D in Georgia: findings from the national seroprevalence survey. Public Health. 2020; 185:341-347. PMC: 7467099. DOI: 10.1016/j.puhe.2020.06.024. View

Poorolajal J, Mahmoodi M, Majdzadeh R, Nasseri-Moghaddam S, Haghdoost A, Fotouhi A . Long-term protection provided by hepatitis B vaccine and need for booster dose: a meta-analysis. Vaccine. 2009; 28(3):623-31. DOI: 10.1016/j.vaccine.2009.10.068. View

Tohme R, Awosika-Olumo D, Nielsen C, Khuwaja S, Scott J, Xing J . Evaluation of hepatitis B vaccine immunogenicity among older adults during an outbreak response in assisted living facilities. Vaccine. 2011; 29(50):9316-20. PMC: 4610903. DOI: 10.1016/j.vaccine.2011.10.011. View

Yang S, Tian G, Cui Y, Ding C, Deng M, Yu C . Factors influencing immunologic response to hepatitis B vaccine in adults. Sci Rep. 2016; 6:27251. PMC: 4914839. DOI: 10.1038/srep27251. View

Liu F, Guo Z, Dong C . Influences of obesity on the immunogenicity of Hepatitis B vaccine. Hum Vaccin Immunother. 2017; 13(5):1014-1017. PMC: 5443393. DOI: 10.1080/21645515.2016.1274475. View

Venkatakrishnan B, Zlotnick A . The Structural Biology of Hepatitis B Virus: Form and Function. Annu Rev Virol. 2016; 3(1):429-451. PMC: 5646271. DOI: 10.1146/annurev-virology-110615-042238. View

Lumeng C, Saltiel A . Inflammatory links between obesity and metabolic disease. J Clin Invest. 2011; 121(6):2111-7. PMC: 3104776. DOI: 10.1172/JCI57132. View

Abd El-Wahab E, Metwally M, Lotfy N . Effectiveness of hepatitis B vaccination in chronic HCV patients after successful generic direct acting antiviral therapy: significance of isolated hepatitis B core antibodies. Trop Med Int Health. 2021; 26(8):882-894. DOI: 10.1111/tmi.13588. View

Chang M, Chen D . Prevention of hepatitis B. Cold Spring Harb Perspect Med. 2015; 5(3):a021493. PMC: 4355249. DOI: 10.1101/cshperspect.a021493. View

10.

Rahmani A, Montecucco A, Kusznir Vitturi B, Debarbieri N, Dini G, Durando P . Long-Term Effectiveness of Hepatitis B Vaccination in the Protection of Healthcare Students in Highly Developed Countries: A Systematic Review and Meta-Analysis. Vaccines (Basel). 2022; 10(11). PMC: 9695994. DOI: 10.3390/vaccines10111841. View

11.

Ley R, Turnbaugh P, Klein S, Gordon J . Microbial ecology: human gut microbes associated with obesity. Nature. 2006; 444(7122):1022-3. DOI: 10.1038/4441022a. View

12.

Souza C, Salgado T, Sardeiro T, Galdino Junior H, Itria A, Tipple A . Post-vaccination anti-HBs testing among healthcare workers: More economical than post-exposure management for Hepatitis B. Rev Lat Am Enfermagem. 2020; 28:e3278. PMC: 7304982. DOI: 10.1590/1518-8345.3534.3278. View

13.

Hassnine A, Saber M, Fouad Y, Sarhan H, Elsayed M, Zaki Z . Clinical study on the efficacy of hepatitis B vaccination in hepatitis C virus related chronic liver diseases in Egypt. Virus Res. 2022; 323:198953. PMC: 10194353. DOI: 10.1016/j.virusres.2022.198953. View

14.

Zhao H, Zhou X, Zhou Y . Hepatitis B vaccine development and implementation. Hum Vaccin Immunother. 2020; 16(7):1533-1544. PMC: 7482909. DOI: 10.1080/21645515.2020.1732166. View