Prevention of Hepatitis B

Overview

Journal Cold Spring Harb Perspect Med

Specialty General Medicine

Date 2015 Mar 4

PMID 25732034

Citations 17

Authors

Mei-Hwei Chang

Ding-Shinn Chen

Affiliations

Soon will be listed here.

Abstract

Hepatitis B virus (HBV) causes life-threatening liver disease. It is transmitted through a horizontal route or a mother-to-infant route, and the latter is the major route in endemic areas. Prevention of HBV infection by immunization is the best way to eliminate HBV-related diseases. The HBV vaccine is the first human vaccine using a viral antigen from infected persons, which is safe and effective. Either passive immunization by hepatitis B immunoglobulin (HBIG) or active immunization by HBV vaccine is effective, and a combination of both yields the best efficacy in preventing HBV infection. The impact of universal HBV immunization is huge, with 90%-95% effectiveness in preventing chronic HBV infection. It is the first cancer preventive vaccine with a protective efficacy against hepatocellular carcinoma (HCC) of ∼ 70%. Nevertheless, further effort is still needed to avoid vaccine failure and to increase the global coverage rate.

Citing Articles

Knowledge, attitudes, and practices toward preventing and controlling hepatitis B virus infection among pregnant women attending antenatal care at a University Hospital in Central Ethiopia: a cross-sectional study.

Larebo Y, Anshebo A, Behera S, Gopalan N Ther Adv Infect Dis. 2024; 11:20499361241285342.

PMID: 39483814 PMC: 11526330. DOI: 10.1177/20499361241285342.

Hepatitis B prevalence and risk factors among adults living with HIV in South Africa: a clinic-based cohort study.

Shivakumar M, Moe C, Bardon A, Krows M, Govere S, Moosa M BMC Infect Dis. 2024; 24(1):891.

PMID: 39215251 PMC: 11365233. DOI: 10.1186/s12879-024-09746-7.

Antiviral Therapy of Chronic Hepatitis B Virus between Present and Future.

Ignat M, Balta A, Barbu R, Draganescu M, Nechita L, Voinescu D J Clin Med. 2024; 13(7).

PMID: 38610820 PMC: 11012273. DOI: 10.3390/jcm13072055.

Global Perspectives on the Hepatitis B Vaccination: Challenges, Achievements, and the Road to Elimination by 2030.

Al-Busafi S, Alwassief A Vaccines (Basel). 2024; 12(3).

PMID: 38543922 PMC: 10975970. DOI: 10.3390/vaccines12030288.

HBV Vaccines: Advances and Development.

Mahmood F, Xu R, Awan M, Song Y, Han Q, Xia X Vaccines (Basel). 2023; 11(12).

PMID: 38140265 PMC: 10747071. DOI: 10.3390/vaccines11121862.

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