Stimuli-Responsive Non-viral Nanoparticles for Gene Delivery

Overview

Journal Handb Exp Pharmacol

Specialty Pharmacology

Date 2023 Aug 29

PMID 37644142

Authors

Lien S Reichel

Anja Traeger

Affiliations

Soon will be listed here.

Abstract

Considering nucleic acids as the language of life and the genome as the instruction manual of cells, their targeted modulation promises great opportunities in treating and healing diseases. In addition to viral gene transfer, the overwhelming power of non-viral mRNA-based vaccines is driving the development of novel gene transporters. Thereby, various nucleic acids such as DNA (pDNA) or RNA (mRNA, siRNA, miRNA, gRNA, or ASOs) need to be delivered, requiring a transporter due to their high molar mass and negative charge in contrast to classical agents. This chapter presents the specific biological hurdles for using nucleic acids and shows how new materials can overcome these.

Citing Articles

mRNA Delivery: Challenges and Advances through Polymeric Soft Nanoparticles.

Yousefi Adlsadabad S, Hanrahan J, Kakkar A Int J Mol Sci. 2024; 25(3).

PMID: 38339015 PMC: 10855060. DOI: 10.3390/ijms25031739.

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