Kinesin Superfamily Member 15 Knockdown Inhibits Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma

Overview

Journal Korean J Physiol Pharmacol

Specialty Pharmacology

Date 2023 Aug 29

PMID 37641808

Authors

Yi Cai

Qianyue Lai

Xuan Zhang

Yu Zhang

Man Zhang

Shaoju Gu

Yuan Qin

Jingshen Hou

Li Zhao

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to investigate the role of kinesin superfamily member 15 (KIF15) in nasopharyngeal carcinogenesis (NPC) and explore its underlying mechanisms. We employed various assays, including the CCK-8 assay, flow cytometry, the Transwell and scratch assay, Western blotting, and nude mice transplantation tumor, to investigate the impact of KIF15 on NPC. Our findings demonstrate that KIF15 plays a critical role in the proliferation, apoptosis, migration, and invasion of NPC cells. Furthermore, we discovered that silencing KIF15 inhibits cell proliferation, migration, and invasion while promoting apoptosis, and that KIF15's effect on NPC cell growth is mediated through the PI3K/AKT and P53 signaling pathways. Additionally, we showed that KIF15 promotes nasopharyngeal cancer cell growth . Our study sheds light on the significance of KIF15 in NPC by revealing that KIF15 knockdown inhibits NPC cell growth through the regulation of AKT-related signaling pathways. These findings suggest that KIF15 represents a promising therapeutic target for the prevention and treatment of NPC.

Citing Articles

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