Ultrasound-triggered Biomimetic Ultrashort Peptide Nanofiber Hydrogels Promote Bone Regeneration by Modulating Macrophage and the Osteogenic Immune Microenvironment

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2023 Aug 28

PMID 37637084

Authors

Fan Zhang

Mingchen Lv

Siyuan Wang

Mengyao Li

Yu Wang

Congjiao Hu

Wei Hu

Xuekui Wang

Xiaogang Wang

Zhiduo Liu

Zhen Fan

Jianzhong Du

Yao Sun

Affiliations

Soon will be listed here.

Abstract

The immune microenvironment plays a vital role in bone defect repair. To create an immune microenvironment that promotes osteogenesis, researchers are exploring ways to enhance the differentiation of M2-type macrophages. Functional peptides have been discovered to effectively improve this process, but they are limited by low efficiency and rapid degradation . To overcome these issues, peptide with both M2 regulatory and self-assembly modules was designed as a building block to construct an ultrasound-responsive nanofiber hydrogel. These nanofibers can be released from hydrogel in a time-dependent manner upon ultrasound stimulation, activating mitochondrial glycolytic metabolism and the tricarboxylic acid cycle, inhibiting reactive oxygen species production and enhancing M2 macrophage polarization. The hydrogel exhibits advanced therapeutic potential for bone regeneration by triggering M2 macrophages to secrete BMP-2 and IGF-I, accelerating the differentiation of bone marrow mesenchymal stem cells (BMSCs) into osteoblasts. Thus, modularly designed biomimetic ultrashort peptide nanofiber hydrogels provide a novel strategy to rebuild osteogenic immune microenvironments for bone repair.

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