An Injectable Shape-adaptive Hydrogel System for Subconjunctival Injuries: and Permanently Releases Rapamycin to Prevent Fibrosis Promoting Autophagy

Overview

Journal Mater Today Bio

Date 2025 Jan 10

PMID 39790484

Authors

Xue Sun

Haohao Cui

Jingfan Li

Boyuan An

Ruixing Liu

Zhihua Guo

Dandan Chu

Xingchen Geng

Bingbing Cui

Lei Zhu

Jingguo Li

Zhanrong Li

Affiliations

Soon will be listed here.

Abstract

Subconjunctival fibrosis (SCF) is a common and refractory eye disease that is a serious threat to vision. The severe side effects of existing drugs and low drug bioavailability due to the ocular barrier are major challenges in SCF treatment. Hence, there is an urgent need to explore safer and more effective strategies for administering anti-SCF drugs. Herein, an injectable and adaptable hydrogel system containing the antifibrotic drug rapamycin was fabricated to address this complex need. This system possesses moderate mechanical properties, self-healing and shape-adaptive capabilities, injectability, and biosafety. It is designed to promote autophagy by modulating the PI3K/AKT/mTOR/WIPI2 pathway, thereby inhibiting SCF. experiments utilizing a rat subconjunctival injury model indicated that administration of this hydrogel system effectively inhibited SCF. This system constitutes a promising method for promoting autophagy to protect against SCF, which will foster its widespread application for other fibrotic diseases.

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