Two-year Follow-up of a Thyroid Cartilage Metastasis from Prostate Cancer: A Case Report

Overview

Journal Radiol Case Rep

Publisher Elsevier

Specialty Radiology

Date 2023 Aug 28

PMID 37636542

Authors

Jana M Kobeissi

Bassem Youssef

Tala Mobayed

Affiliations

Soon will be listed here.

Abstract

Few case reports describe metastatic prostate cancer to the thyroid cartilage. While earlier reports identified the metastatic lesions upon developing symptoms, more recent ones have detected them via prostate-specific membrane antigen positron emission tomography (PSMA PET). Herein, we report the case of a patient with metastatic castrate-resistant prostate cancer and a PSMA PET-detected lesion in the thyroid cartilage. Over the course of 2 years, he received multiple lines of chemotherapy and hormonal therapy, and his overall disease status fluctuated - some nodal and bony metastases resolved while others appeared anew. His thyroid cartilage lesion, however, slowly progressed in a consistent fashion with increasing uptake on successive PSMA PET images. Apart from mild dysphonia, the patient remained to be asymptomatic from this lesion, and no local therapies were used. To our knowledge, this is the first close follow-up of prostate cancer metastatic to the thyroid cartilage, shedding light on the course of such lesions and helping answer management-related questions, which are particularly relevant as more occult metastases are discovered in the PSMA PET era.

References

Gandaglia G, Abdollah F, Schiffmann J, Trudeau V, Shariat S, Kim S . Distribution of metastatic sites in patients with prostate cancer: A population-based analysis. Prostate. 2013; 74(2):210-6. DOI: 10.1002/pros.22742. View

Shaygan B, Zukotynski K, Benard F, Menard C, Kuk J, Sistani G . Canadian Urological Association best practice report: Prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) and PET/magnetic resonance (MR) in prostate cancer. Can Urol Assoc J. 2021; 15(6):162-172. PMC: 8195587. DOI: 10.5489/cuaj.7268. View

Molina Escudero R, Herranz Amo F, Navas Martinez M, Tabares Jimenez J, Husillos Alonso A, Ogaya Pinies G . Metastatic prostate cancer on the thyroid cartilage: unusual symptoms of prostatic adenocarcinoma. Case report. Arch Esp Urol. 2011; 64(2):132-5. View

Hessan H, Strauss M, Sharkey F . Urogenital tract carcinoma metastatic to the head and neck. Laryngoscope. 1986; 96(12):1352-6. DOI: 10.1288/00005537-198612000-00007. View

Gao J, Myuran T, Chaurasia M . Metastasis of prostate carcinoma to the thyroid cartilage presenting with airway obstruction. BMJ Case Rep. 2021; 14(2). PMC: 7896564. DOI: 10.1136/bcr-2020-240396. View

Tupalli A, Damle N, Thankarajan A, Mangu B, Kumar A, Khan D . An Unusual Case of Simultaneous Cricoid and Thyroid Cartilage Metastases from Prostatic Adenocarcinoma on Ga-PSMA PET/CT. Nucl Med Mol Imaging. 2020; 54(1):61-62. PMC: 7062982. DOI: 10.1007/s13139-019-00625-7. View

Shetty D, Patel D, Le K, Bui C, Mansberg R . Pitfalls in Gallium-68 PSMA PET/CT Interpretation-A Pictorial Review. Tomography. 2018; 4(4):182-193. PMC: 6299744. DOI: 10.18383/j.tom.2018.00021. View

Afshar-Oromieh A, Zechmann C, Malcher A, Eder M, Eisenhut M, Linhart H . Comparison of PET imaging with a (68)Ga-labelled PSMA ligand and (18)F-choline-based PET/CT for the diagnosis of recurrent prostate cancer. Eur J Nucl Med Mol Imaging. 2013; 41(1):11-20. PMC: 3843747. DOI: 10.1007/s00259-013-2525-5. View

Tsechelidis I, Vrachimis A . PSMA PET in Imaging Prostate Cancer. Front Oncol. 2022; 12:831429. PMC: 8832487. DOI: 10.3389/fonc.2022.831429. View

10.

Selimoglu H, Duran C, Saraydaroglu O, Guclu M, Kiyici S, Ersoy C . Prostate cancer metastasis to thyroid gland. Tumori. 2007; 93(3):292-5. View

11.

QUINN Jr F, McCabe B . Laryngeal metastases from malignant tumors in distant organs. Ann Otol Rhinol Laryngol. 1957; 66(1):139-43. DOI: 10.1177/000348945706600110. View

12.

Hubner N, Shariat S, Remzi M . Prostate biopsy: guidelines and evidence. Curr Opin Urol. 2018; 28(4):354-359. DOI: 10.1097/MOU.0000000000000510. View

13.

Annovazzi A, Faiella A, Pescarmona E, Sanguineti G, Sciuto R . Asymptomatic Metastasis to Thyroid Cartilage Detected by 18F-Choline and 64Cu-PSMA PET/CT as a Single Site of Disease Relapse in a Patient With Castration-Resistant Prostate Carcinoma. Clin Nucl Med. 2019; 45(3):214-216. DOI: 10.1097/RLU.0000000000002786. View

14.

Ehrlich A . Tumor involving the laryngeal cartilages. AMA Arch Otolaryngol. 1954; 59(2):178-85. DOI: 10.1001/archotol.1954.00710050190008. View

15.

Prescher A, Schick B, Stutz A, Brors D . Laryngeal prostatic cancer metastases: an underestimated route of metastases?. Laryngoscope. 2002; 112(8 Pt 1):1467-73. DOI: 10.1097/00005537-200208000-00026. View

16.

Gupta N, Verma R, Belho E . Metastatic Thyroid Cartilage Lesion from Prostatic Adenocarcinoma on Ga-Prostate-Specific Membrane Antigen Positron Emission Tomography-Computed Tomography Scan: Case Series. Indian J Nucl Med. 2021; 36(2):183-188. PMC: 8320823. DOI: 10.4103/ijnm.ijnm_218_20. View

17.

Nohara T, Kawashima A, Takahashi T, Kitamura M, Akai H, Oka T . [Prostate cancer metastasized to thyroid cartilage: a case report]. Nihon Hinyokika Gakkai Zasshi. 2005; 96(7):697-700. DOI: 10.5980/jpnjurol1989.96.697. View

18.

Torre L, Siegel R, Ward E, Jemal A . Global Cancer Incidence and Mortality Rates and Trends--An Update. Cancer Epidemiol Biomarkers Prev. 2015; 25(1):16-27. DOI: 10.1158/1055-9965.EPI-15-0578. View

19.

Park Y, Park M . Vocal cord paralysis from prostatic carcinoma metastasizing to the larynx. Head Neck. 1993; 15(5):455-8. DOI: 10.1002/hed.2880150515. View