Alpha 2.0
Login Register
» Articles » PMID: 37623488

Associations of Adipocytokines and Early Renal Dysfunction in Young People on the Background of Dyslipidemia

Overview
Journal J Pers Med
Date 2023 Aug 25
PMID 37623488
Authors
Evgeniia V Garbuzova
Alyona D Khudiakova
Lilia V Shcherbakova
Elena V Kashtanova
Yana V Polonskaya
Ekaterina M Stakhneva
Yulia I Ragino
Affiliations
Soon will be listed here.
Abstract

Background: There are data supporting the idea that atherogenic dyslipidemia is a risk factor for CKD and reduced GFR. The aim was to evaluate the associations between adipocytokines and early renal dysfunction in young people with dyslipidemia.

Materials And Methods: A population study was conducted in IIPM-Branch of IC&G SB RAS, in 2013-2017. Furthermore, 1033 people were included in the study (469 men (45.4%) and 564 women (54.6%)). The study included blood sampling, anthropometric data, and adipokines by multiplex analysis.

Results: Among people with reduced kidney function and DLP, men were 3.1 times more common than without DLP, women smoked 2 times less often, arterial hypertension was 7.8 times more common, and abdominal obesity was 2.7 times more common (and women with DLP were 3 times more likely than those without DLP). An increase in the level of resistin by 1 mcg/mL was associated with an increased chance of having renal dysfunction by 0.2%. An increase in the level of GIP was associated with an increased chance of having renal dysfunction by 1.1%.

Conclusions: In young people with dyslipidemia, regardless of the presence of abdominal obesity, resistin and GIP are associated with the presence of renal dysfunction.

References
1.
Rapa S, Di Iorio B, Campiglia P, Heidland A, Marzocco S . Inflammation and Oxidative Stress in Chronic Kidney Disease-Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites. Int J Mol Sci. 2020; 21(1). PMC: 6981831. DOI: 10.3390/ijms21010263. View
2.
Meier J, Nauck M, Kranz D, Holst J, Deacon C, Gaeckler D . Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects. Diabetes. 2004; 53(3):654-62. DOI: 10.2337/diabetes.53.3.654. View
3.
Kuma A, Uchino B, Ochiai Y, Kawashima M, Enta K, Tamura M . Impact of low-density lipoprotein cholesterol on decline in estimated glomerular filtration rate in apparently healthy young to middle-aged working men. Clin Exp Nephrol. 2017; 22(1):15-27. DOI: 10.1007/s10157-017-1407-8. View
4.
Tsuruya K, Yoshida H, Nagata M, Kitazono T, Iseki K, Iseki C . Impact of the Triglycerides to High-Density Lipoprotein Cholesterol Ratio on the Incidence and Progression of CKD: A Longitudinal Study in a Large Japanese Population. Am J Kidney Dis. 2015; 66(6):972-83. DOI: 10.1053/j.ajkd.2015.05.011. View
5.
Lv J, Zhang L . Prevalence and Disease Burden of Chronic Kidney Disease. Adv Exp Med Biol. 2019; 1165:3-15. DOI: 10.1007/978-981-13-8871-2_1. View