Impact of Low-density Lipoprotein Cholesterol on Decline in Estimated Glomerular Filtration Rate in Apparently Healthy Young to Middle-aged Working Men

Overview

Journal Clin Exp Nephrol

Publisher Springer

Specialty Nephrology

Date 2017 Apr 8

PMID 28386655

Citations 17

Authors

Akihiro Kuma

Bungo Uchino

Yoko Ochiai

Masatoshi Kawashima

Kazuhiko Enta

Masahito Tamura

Yutaka Otsuji

Akihiko Kato

Affiliations

Soon will be listed here.

Abstract

Background: It remains to be fully clarified whether there is a relationship between uncontrolled dyslipidemia and decline in estimated glomerular filtration rate (eGFR) in the general population. Therefore, this study's aim was to test the association of dyslipidemia with changes in eGFR in apparently healthy working men.

Methods: We retrospectively examined the annual medical check-up list of 14,510 male workers aged 20-60 years with eGFR ≥ 60 mL/min/1.73 m at baseline, and then evaluated the association of the changes in the check-up parameters with a decline in eGFR during the 5-year observation period.

Results: Mean age and eGFR were 38.5 years and 82.3 mL/min/1.73 m at baseline, respectively. Evaluated low-density lipoprotein cholesterol (LDL-C) (≥140 mg/dL) was a strong indicator of CKD development in participants (basal eGFR 60-90 mL/min/1.73 m) without hypertension [odds ratio (95% confidence interval): 1.46 (1.12-1.90)] or diabetes mellitus (DM) [1.49 (1.23-1.82)]. When LDL-C normalized under 140 mg/dL during follow-up, the decline in eGFR was smaller in non-hypertensive participants [-5.9 (-14.4 to -0.9) vs -13.4 (-18.4 to -4.5) mL/min/1.73 m, p < 0.05]. There was an inverse correlation between change of LDL-C and decline in eGFR (p for trend <0.001).

Conclusion: Increased LDL-C levels are associated with the development of incident CKD and eGFR decline in young to middle-aged working men without hypertension and/or DM.

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