On the Way to Potential Antifungal Compounds: Synthesis and Activity of 2-benzofuranylacetic Acid Amides

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2023 Aug 25

PMID 37622023

Authors

Camilo Mahecha-Mahecha

Paola Borrego-Munoz

Luis M Pombo

Diego Gamba-Sanchez

Affiliations

Soon will be listed here.

Abstract

Crop losses caused by microbial infections are a significant global issue, especially in tropical regions. The development of novel antimicrobial agents, particularly antifungal agents, has been explored from various perspectives, including chemical synthesis. However, conventional approaches typically involve synthesizing new and potent compounds on a small scale (a few milligrams), making the scale-up of the reaction a major challenge. In this manuscript, we present a method for the synthesis of new and active (against ) benzofuranyl acetic acid amides. Our strategy allows us to synthesize the key precursor on the gram scale, enabling the production of sufficient quantities of other active compounds within short timeframes for conducting biological studies. All the reactions used in this manuscript are recognized by their industrial application.

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