Towards Potential Antifungal Agents: Synthesis, Supramolecular Self-assembly and Activity of Azole Mono-, Sesqui- and Diterpenoids

Terpenes and their derivatives are natural antifungal and antimicrobial agents. In this paper, potential antifungal agents were developed on the basis of farnesol, geraniol, myrtenol, perillyl alcohol, cedrol and phytol. The synthesized compounds exist in aqueous solutions as stable associates ( = 142-216 nm, PDI 0.04-0.16, = +0.9-+46 mV). Formation of stable associates of the compounds in solution promotes compaction and dosed release of the drug. The membranotropic activity of the compounds was also investigated to open up their possible application in the treatment of skin diseases. The relationship between membranotropism and lipophilicity coefficient (log ) has been established. The antifungal and antimicrobial activities of the obtained compounds were studied on the clinical isolate of sp., , yeast , Gram-negative () and Gram-positive (, ) bacteria. sp. (0.0781 mg mL) and (0.0049 mg mL) showed the highest sensitivity to the agents.