Precision Nutrition to Improve Risk Factors of Obesity and Type 2 Diabetes
Overview
Authors
Affiliations
Purpose Of Review: Existing dietary and lifestyle interventions and recommendations, to improve the risk factors of obesity and type 2 diabetes with the target to mitigate this double global epidemic, have produced inconsistent results due to interpersonal variabilities in response to these conventional approaches, and inaccuracies in dietary assessment methods. Precision nutrition, an emerging strategy, tailors an individual's key characteristics such as diet, phenotype, genotype, metabolic biomarkers, and gut microbiome for personalized dietary recommendations to optimize dietary response and health. Precision nutrition is suggested to be an alternative and potentially more effective strategy to improve dietary intake and prevention of obesity and chronic diseases. The purpose of this narrative review is to synthesize the current research and examine the state of the science regarding the effect of precision nutrition in improving the risk factors of obesity and type 2 diabetes.
Recent Findings: The results of the research review indicate to a large extent significant evidence supporting the effectiveness of precision nutrition in improving the risk factors of obesity and type 2 diabetes. Deeper insights and further rigorous research into the diet-phenotype-genotype and interactions of other components of precision nutrition may enable this innovative approach to be adapted in health care and public health to the special needs of individuals. Precision nutrition provides the strategy to make individualized dietary recommendations by integrating genetic, phenotypic, nutritional, lifestyle, medical, social, and other pertinent characteristics about individuals, as a means to address the challenges of generalized dietary recommendations. The evidence presented in this review shows that precision nutrition markedly improves risk factors of obesity and type 2 diabetes, particularly behavior change.
Ahmed S, Adnan H, Khawaja M, Butler A Int J Mol Sci. 2025; 26(2).
PMID: 39859467 PMC: 11765584. DOI: 10.3390/ijms26020753.
The Contribution of Precision Nutrition Intervention in Subfertile Couples.
Monteiro J, Bicho M, Valente A Nutrients. 2025; 17(1.
PMID: 39796537 PMC: 11722978. DOI: 10.3390/nu17010103.
Parpori M, Tsamesidis I, Karamitrousis E, Giakidou A, Kroustalidou E, Liamopoulou P J Pers Med. 2024; 14(12).
PMID: 39728067 PMC: 11677013. DOI: 10.3390/jpm14121154.
Precision or Personalized Nutrition: A Bibliometric Analysis.
Hinojosa-Nogueira D, Subiri-Verdugo A, Diaz-Perdigones C, Rodriguez-Munoz A, Vilches-Perez A, Mela V Nutrients. 2024; 16(17).
PMID: 39275239 PMC: 11397555. DOI: 10.3390/nu16172922.
Singh V, Hu X, Singh A, Solanki M, Vijayaraghavan P, Srivastav R Front Nutr. 2024; 11:1427608.
PMID: 39183982 PMC: 11341379. DOI: 10.3389/fnut.2024.1427608.