Nipah Virus Aerosol Challenge of Three Distinct Particle Sizes in Nonhuman Primates

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2023 Aug 23

PMID 37610582

Authors

Matthew G Lackemeyer

J Kyle Bohannon

Michael R Holbrook

Affiliations

Soon will be listed here.

Abstract

Aerosol and inhalational studies of high-consequence pathogens allow researchers to study the disease course and effects of biologicals transmitted through aerosol in a laboratory-controlled environment. Inhalational studies involving Nipah virus with small (1-3 μm), intermediate (6-8 μm), and large particles (10-14 μm) were explored in African green nonhuman primates to determine if the subsequent disease course more closely recapitulated what is observed in Nipah virus human disease. The aerosol procedures outlined describe the different equipment/techniques used to generate the three particle sizes and control the site of particle deposition within this animal model.

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