Genotyping and Population Characteristics of the China Kadoorie Biobank

Overview

Journal Cell Genom

Date 2023 Aug 21

PMID 37601966

Authors

Robin G Walters

Iona Y Millwood

Kuang Lin

Dan Schmidt Valle

Pandora McDonnell

Alex Hacker

Daniel Avery

Ahmed Edris

Hannah Fry

Na Cai

Warren W Kretzschmar

M Azim Ansari

Paul A Lyons

Rory Collins

Peter Donnelly

Michael Hill

Richard Peto

Hongbing Shen

Xin Jin

Chao Nie

Xun Xu

Yu Guo

Canqing Yu

Jun Lv

Robert J Clarke

Liming Li

Zhengming Chen

Affiliations

Soon will be listed here.

Abstract

The China Kadoorie Biobank (CKB) is a population-based prospective cohort of >512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across China. Detailed data from questionnaires and physical measurements were collected at baseline, with additional measurements at three resurveys involving ∼5% of surviving participants. Analyses of genome-wide genotyping, for >100,000 participants using custom-designed Axiom arrays, reveal extensive relatedness, recent consanguinity, and signatures reflecting large-scale population movements from recent Chinese history. Systematic genome-wide association studies of incident disease, captured through electronic linkage to death and disease registries and to the national health insurance system, replicate established disease loci and identify 14 novel disease associations. Together with studies of candidate drug targets and disease risk factors and contributions to international genetics consortia, these demonstrate the breadth, depth, and quality of the CKB data. Ongoing high-throughput omics assays of collected biosamples and planned whole-genome sequencing will further enhance the scientific value of this biobank.

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