No Obesity Paradox in Out-of-hospital Cardiac Arrest: Data from the Swedish Registry of Cardiopulmonary Resuscitation

Overview

Journal Resusc Plus

Date 2023 Aug 21

PMID 37601410

Authors

Alfred Hjalmarsson

Araz Rawshani

Truls Ramunddal

Aidin Rawshani

Clara Hjalmarsson

Anna Myredal

Gudrun Hoskuldsdottir

Fredrik Hessulf

Geir Hirlekar

Oskar Angeras

Petur Petursson

Affiliations

Soon will be listed here.

Abstract

Background: Although an "obesity paradox", which states an increased chance of survival for patients with obesity after myocardial infarction has been proposed, it is less clear whether this phenomenon even exists in patients suffering out-of-hospital cardiac arrest (OHCA) and if diabetes, which is often associated with obesity, implies an additional risk.

Objective: To investigate if and how obesity, with or without diabetes, affects the survival of patients with OHCA.

Methods: This study included 55,483 patients with OHCA reported to the Swedish Registry of Cardiopulmonary Resuscitation between 2010 and 2020. Patients were classified in five groups: obesity only (Ob), type 1 diabetes only (T1D), type 2 diabetes only (T2D), obesity and any diabetes (ObD), or belonging to the group other (OTH). Patient characteristics and outcomes were studied using descriptive statistics, logistic, and Cox proportional regression.

Results: Obesity only was found in 2.7% of the study cohort, while 3.2% had obesity and any type of diabetes. Ob patients were significantly younger than all other patients (p ≤ 0.001); the 30 day-survival was 9.6% in Ob, and 10.6%, 7.3%, 6.9%, and 12.7% in T1D, T2D, ObD, and OTH, respectively, with OR (95% CI) of 0.69 (0.57-0.82), 0.78 (0.56-1.05), 0.65 (0.59-0.71), and 0.55 (0.45-0.66) for Ob, T1D, T2D, and ObD, respectively (reference group OTH). No time-related trends in 30-days survival were found.

Conclusion: Obesity was present in 6% of the population and was associated with younger age and a 30% reduction in survival; a combination of obesity and diabetes further reduced the survival rate.

Citing Articles

Cardiopulmonary resuscitation in obese patients: A scoping review.

Considine J, Couper K, Greif R, Ong G, Smyth M, Ng K Resusc Plus. 2024; 20:100820.

PMID: 39618429 PMC: 11607644. DOI: 10.1016/j.resplu.2024.100820.

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