Spatial Promoter-enhancer Hubs in Cancer: Organization, Regulation, and Function

Overview

Journal Trends Cancer

Publisher Cell Press

Specialty Oncology

Date 2023 Aug 20

PMID 37599153

Authors

Jingru Zhao

Robert B Faryabi

Affiliations

Soon will be listed here.

Abstract

Transcriptional dysregulation is a hallmark of cancer and can be driven by altered enhancer landscapes. Recent studies in genome organization have revealed that multiple enhancers and promoters can spatially coalesce to form dynamic topological assemblies, known as promoter-enhancer hubs, which strongly correlate with elevated gene expression. In this review, we discuss the structure and complexity of promoter-enhancer hubs recently identified in multiple cancer types. We further discuss underlying mechanisms driving dysregulation of promoter-enhancer hubs and speculate on their functional role in pathogenesis. Understanding the role of promoter-enhancer hubs in transcriptional dysregulation can provide insight into new therapeutic approaches to target these complex features of genome organization.

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