The Implications of N6-methyladenosine (m6A) Modification in Esophageal Carcinoma

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2023 Aug 20

PMID 37598390

Authors

Cheng He

Xiao Teng

Luming Wang

Miaoqi Ni

Linhai Zhu

Jiacong Liu

Wang Lv

Jian Hu

Affiliations

Soon will be listed here.

Abstract

Esophageal carcinoma (EC) is always diagnosed at advanced stage and its the mortality rate remains high. The patients usually miss the best opportunity for treatment because of non-specific symptoms and the survival rates are low. N6-methyladenosine (m6A) the predominant modification in eukaryotic messenger RNA(mRNA), serves vital roles in numerous bioprocess. This chemical modification is dynamic, reversible and consists of three regulators: m6A methyltransferases (writers), demethylases (erasers) and m6A-binding proteins (readers). Recently, a growing number of evidences have indicated relationships between m6A and EC. Whereas, lacking of cognition about the molecular mechanism of m6A modification in esophageal carcinoma. We will focus on the biological function roles of m6A modification in the tumorigenesis and development of EC. Recent studies showed that immunotherapy had a positive impact on EC. The relationship between m6A and immunotherapy in EC deserves further research and discussion. We will also discuss the potential clinical applications regarding diagnosis, treatment and prognosis of m6A modification for EC and provide perspectives for further studies.

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