MA Methylation: a Potential Key Player in Understanding and Treating COVID-2019 Infection

Overview

Journal Cell Death Discov

Date 2023 Aug 18

PMID 37596265

Authors

Weiwei Qian

Jian Zhou

Ligeng Duan

Haoyu Wang

Shuyun Xu

Yu Cao

Affiliations

Soon will be listed here.

Abstract

Since its discovery in 2019, coronavirus disease 2019 (COVID-2019) spans a wide clinical spectrum from the asymptomatic stage, mild infection, to severe pneumonia. In patients with COVID-2019, factors such as advanced age, diabetes, or hypertension are associated with a significantly increased risk of severe diseases and death. Of note, the mechanisms underlying differences in the risk and symptoms of COVID-2019 among different populations are still poorly characterized. Accordingly, it is imperative to elucidate potential pathophysiological mechanisms and develop targeted therapeutic approaches for COVID-2019 infection. N6-methyladenosine (mA) is one of the most common modifications in mammalian RNA transcripts and is widely found in messenger RNAs and some non-coding RNAs. It has been reported that mA methylation modifications are present in viral RNA transcripts, which are of great significance for the regulation of the viral life cycle. Furthermore, mA methylation has recently been found to be strongly associated with COVID-2019 infection. Therefore, this article reviews recent advances in studies related to the role of mA methylation in COVID-2019 infection.

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