[Research Progress on Medical Devices of Polyhydroxyalkanoate in Orthopedics]

Overview

Journal Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi

Specialty General Surgery

Date 2023 Aug 16

PMID 37586789

Authors

DaiXu Wei

Youguo Tan

Affiliations

Soon will be listed here.

Abstract

Objective: To review the research progress of natural biomaterial polyhydroxyalkanoate (PHA) in orthopedics.

Methods: The literature concerning PHA devices for bone defects, bone repair, and bone neoplasms, respectively, in recent years was extensively consulted. The three aspects of the advantages of PHA in bone repair, the preparation of PHA medical devices for bone repair and their application in orthopedics were discussed.

Results: Due to excellent biodegradability, biocompatibility, and potential osteoinduction, PHA is a kind of good bone repair material. In addition to the traditional PHA medical implants, the use of electrostatic spinning and three-dimensional printing can be designed to various functional PHA medical devices, in order to meet the orthopedic clinical demands, including the bone regeneration, minimally invasive bone tissue repair by injection, antibacterial bone repair, auxiliary establishment of three-dimensional bone tumor model, directed osteogenic differentiation of stem cells, .

Conclusion: At present, PHA is a hotspot of biomaterials for translational medicine in orthopedics. Although they have not completely applied in the clinic, the advantages of repair in bone defects have been gradually reflected in tissue engineering, showing an application prospect in orthopedics.

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