Task-residual Effective Connectivity of Motor Network in Transient Ischemic Attack

Overview

Journal Commun Biol

Specialty Biology

Date 2023 Aug 14

PMID 37580508

Authors

Truc Chu

Seonjin Lee

Il-Young Jung

Youngkyu Song

Hyun-Ah Kim

Jong Wook Shin

Sungho Tak

Affiliations

Soon will be listed here.

Abstract

Transient ischemic attack (TIA) is a temporary episode of neurological dysfunction that results from focal brain ischemia. Although TIA symptoms are quickly resolved, patients with TIA have a high risk of stroke and persistent impairments in multiple domains of cognitive and motor functions. In this study, using spectral dynamic causal modeling, we investigate the changes in task-residual effective connectivity of patients with TIA during fist-closing movements. 28 healthy participants and 15 age-matched patients with TIA undergo functional magnetic resonance imaging at 7T. Here we show that during visually cued motor movement, patients with TIA have significantly higher effective connectivity toward the ipsilateral primary motor cortex and lower connectivity to the supplementary motor area than healthy controls. Our results imply that TIA patients have aberrant connections among motor regions, and these changes may reflect the decreased efficiency of primary motor function and disrupted control of voluntary movement in patients with TIA.

References

Johnston S, Rothwell P, Nguyen-Huynh M, Giles M, Elkins J, Bernstein A . Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet. 2007; 369(9558):283-92. DOI: 10.1016/S0140-6736(07)60150-0. View

Rosenberg M, Finn E . How to establish robust brain-behavior relationships without thousands of individuals. Nat Neurosci. 2022; 25(7):835-837. DOI: 10.1038/s41593-022-01110-9. View

Wu T, Long X, Wang L, Hallett M, Zang Y, Li K . Functional connectivity of cortical motor areas in the resting state in Parkinson's disease. Hum Brain Mapp. 2010; 32(9):1443-57. PMC: 6870250. DOI: 10.1002/hbm.21118. View

Castiello U, Begliomini C . The cortical control of visually guided grasping. Neuroscientist. 2008; 14(2):157-70. DOI: 10.1177/1073858407312080. View

van Rooij F, Schaapsmeerders P, Maaijwee N, van Duijnhoven D, de Leeuw F, Kessels R . Persistent cognitive impairment after transient ischemic attack. Stroke. 2014; 45(8):2270-4. DOI: 10.1161/STROKEAHA.114.005205. View

Ashburner J, Friston K . Unified segmentation. Neuroimage. 2005; 26(3):839-51. DOI: 10.1016/j.neuroimage.2005.02.018. View

Wang Y, Wang Y, Zhao X, Liu L, Wang D, Wang C . Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med. 2013; 369(1):11-9. DOI: 10.1056/NEJMoa1215340. View

Grefkes C, Eickhoff S, Nowak D, Dafotakis M, Fink G . Dynamic intra- and interhemispheric interactions during unilateral and bilateral hand movements assessed with fMRI and DCM. Neuroimage. 2008; 41(4):1382-94. DOI: 10.1016/j.neuroimage.2008.03.048. View

Gratton C, Nelson S, Gordon E . Brain-behavior correlations: Two paths toward reliability. Neuron. 2022; 110(9):1446-1449. DOI: 10.1016/j.neuron.2022.04.018. View

10.

Sharma N, Baron J, Rowe J . Motor imagery after stroke: relating outcome to motor network connectivity. Ann Neurol. 2009; 66(5):604-16. PMC: 3791355. DOI: 10.1002/ana.21810. View

11.

Fitzpatrick T, Gocan S, Wang C, Hamel C, Bourgoin A, Dowlatshahi D . How do neurologists diagnose transient ischemic attack: A systematic review. Int J Stroke. 2018; 14(2):115-124. PMC: 6604401. DOI: 10.1177/1747493018816430. View

12.

Razi A, Kahan J, Rees G, Friston K . Construct validation of a DCM for resting state fMRI. Neuroimage. 2014; 106:1-14. PMC: 4295921. DOI: 10.1016/j.neuroimage.2014.11.027. View

13.

Simmatis L, Krett J, Scott S, Jin A . Robotic exoskeleton assessment of transient ischemic attack. PLoS One. 2017; 12(12):e0188786. PMC: 5741219. DOI: 10.1371/journal.pone.0188786. View

14.

L Seghier M, Zeidman P, Neufeld N, Leff A, Price C . Identifying abnormal connectivity in patients using dynamic causal modeling of FMRI responses. Front Syst Neurosci. 2010; 4. PMC: 2936900. DOI: 10.3389/fnsys.2010.00142. View

15.

Nachev P, Kennard C, Husain M . Functional role of the supplementary and pre-supplementary motor areas. Nat Rev Neurosci. 2008; 9(11):856-69. DOI: 10.1038/nrn2478. View

16.

Jenkins I, Jahanshahi M, Jueptner M, Passingham R, Brooks D . Self-initiated versus externally triggered movements. II. The effect of movement predictability on regional cerebral blood flow. Brain. 2000; 123 ( Pt 6):1216-28. DOI: 10.1093/brain/123.6.1216. View

17.

Davies-Thompson J, Andrews T . Intra- and interhemispheric connectivity between face-selective regions in the human brain. J Neurophysiol. 2012; 108(11):3087-95. PMC: 3544867. DOI: 10.1152/jn.01171.2011. View

18.

Albers G, Caplan L, Easton J, Fayad P, Mohr J, Saver J . Transient ischemic attack--proposal for a new definition. N Engl J Med. 2002; 347(21):1713-6. DOI: 10.1056/NEJMsb020987. View

19.

Easton J, Saver J, Albers G, Alberts M, Chaturvedi S, Feldmann E . Definition and evaluation of transient ischemic attack: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on.... Stroke. 2009; 40(6):2276-93. DOI: 10.1161/STROKEAHA.108.192218. View

20.

Wang L, Zhang Y, Zhang J, Sang L, Li P, Yan R . Aging Changes Effective Connectivity of Motor Networks During Motor Execution and Motor Imagery. Front Aging Neurosci. 2019; 11:312. PMC: 6881270. DOI: 10.3389/fnagi.2019.00312. View