Balancing Lysosome Abundance in Health and Disease

Overview

Journal Nat Cell Biol

Specialty Cell Biology

Date 2023 Aug 14

PMID 37580388

Authors

Anders P Mutvei

Michal J Nagiec

John Blenis

Affiliations

Soon will be listed here.

Abstract

Lysosomes are catabolic organelles that govern numerous cellular processes, including macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in lysosome abundance are implicated in human diseases. Here we outline the mechanisms of lysosome biogenesis and turnover, and discuss how changes in the lysosome pool impact physiological and pathophysiological processes.

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