Association of 3p21.31 Locus (CXCR6 and LZTFL1) with COVID-19 Outcomes in Brazilian Hospitalyzed Subjects

Overview

Journal Curr Microbiol

Specialty Microbiology

Date 2023 Aug 14

PMID 37578643

Authors

Joao Locke Ferreira de Araujo

Victoria Frigerio Bonifacio

Lorena Medeiros Batista

Renata Eliane de Avila

Renato Santana Aguiar

Luciana Bastos-Rodrigues

Renan Pedra de Souza

Affiliations

Soon will be listed here.

Abstract

The 3p21.31 locus has been associated with severe COVID-19 prognosis in GWAS studies. Here, we evaluated whether three polymorphisms (LZTFL1 rs10490770, CXCR6 rs2234355 and rs2234358) in the reported locus were associated with the need for mechanical ventilation, hospitalization length and death in 102 COVID-19 hospitalized Brazilian subjects. No genetic association was found with the need for mechanical ventilation and hospitalization length. CXCR6 rs2234355 was associated with mortality under the codominance model, with carriers of the A/A genotype having a greater chance of death than A/G (OR: 10.5; 95% CI: 1.55-70.76). Our results further suggest that the CXCR6 genetic variant contributes to COVID-19 outcomes.

Citing Articles

Genetic determinants of COVID-19 severity and mortality: Alu 287 bp polymorphism and , , expression in hospitalized patients.

de Araujo J, Rossi A, de Almeida J, Alves H, Leitao I, de Avila R PeerJ. 2025; 13():e18508.

PMID: 39850833 PMC: 11756369. DOI: 10.7717/peerj.18508.

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