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Obesity and Diabetes As High-risk Factors for Severe Coronavirus Disease 2019 (Covid-19)

Overview
Specialty Endocrinology
Date 2020 Jun 27
PMID 32588943
Citations 257
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Abstract

The outbreak of the coronavirus disease 2019 (Covid-19) has become an evolving worldwide health crisis. With the rising prevalence of obesity and diabetes has come an increasing awareness of their impacts on infectious diseases, including increased risk for various infections, post-infection complications and mortality from critical infections. Although epidemiological and clinical characteristics of Covid-19 have been constantly reported, no article has systematically illustrated the role of obesity and diabetes in Covid-19, or how Covid-19 affects obesity and diabetes, or special treatment in these at-risk populations. Here, we present a synthesis of the recent advances in our understanding of the relationships between obesity, diabetes and Covid-19 along with the underlying mechanisms, and provide special treatment guidance for these at-risk populations.

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References
1.
Hameed I, Masoodi S, Mir S, Nabi M, Ghazanfar K, Ganai B . Type 2 diabetes mellitus: From a metabolic disorder to an inflammatory condition. World J Diabetes. 2015; 6(4):598-612. PMC: 4434080. DOI: 10.4239/wjd.v6.i4.598. View

2.
Vangipuram S, Sheele J, Atkinson R, Holland T, Dhurandhar N . A human adenovirus enhances preadipocyte differentiation. Obes Res. 2004; 12(5):770-7. DOI: 10.1038/oby.2004.93. View

3.
Defuria J, Belkina A, Jagannathan-Bogdan M, Snyder-Cappione J, Carr J, Nersesova Y . B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile. Proc Natl Acad Sci U S A. 2013; 110(13):5133-8. PMC: 3612635. DOI: 10.1073/pnas.1215840110. View

4.
Wu Z, McGoogan J . Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020; 323(13):1239-1242. DOI: 10.1001/jama.2020.2648. View

5.
Cho W, Lee D, Lee S, Sohn S, Park H, Park Y . Diet-induced obesity reduces the production of influenza vaccine-induced antibodies via impaired macrophage function. Acta Virol. 2016; 60(3):298-306. DOI: 10.4149/av_2016_03_298. View