Expanding the Chemical Diversity of Secondary Metabolites Produced by Two Marine-Derived Enterocin- and Wailupemycin-Producing Strains

Overview

Journal ACS Omega

Publisher American Chemical Society

Specialty Chemistry

Date 2023 Aug 14

PMID 37576654

Authors

Kunyu Xia

Jiaxu Shang

Jiwen Sun

Weiming Zhu

Peng Fu

Affiliations

Soon will be listed here.

Abstract

To expand the chemical diversity of secondary metabolites produced by two marine-derived enterocin- and wailupemycin-producing strains, OUCMDZ-3434 and OUCMDZ-2599, precursor feeding and solid fermentation strategies were used. Two new compounds, wailupemycins Q () and R (), were isolated from the extracts of liquid and solid fermentation of OUCMDZ-3434. Furthermore, during the fermentation of OUCMDZ-3434, -fluorobenzoic acid was added as the key biosynthetic precursor, which resulted in the isolation of eight new fluorinated enterocin and wailupemycin derivatives (-) and 10 previously reported analogues (-). From the solid fermentation extract of OUCMDZ-2599, a new sulfur-containing compound thiotetromycin B () and its known analogue thiotetromycin () were identified. Moreover, the solid fermentation strategy effectively activated the biosynthesis of siderophores (-) of strain OUCMDZ-2599. Compound showed moderate antibacterial activity against and methicillin-resistant subsp. with MIC values of 4 μg/mL. Compounds - were significantly capable of binding Fe(III).

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