New α-glucosidase Inhibitors from Marine Algae-derived Streptomyces Sp. OUCMDZ-3434

Overview

Journal Sci Rep

Specialty Science

Date 2016 Jan 30

PMID 26822662

Citations 13

Authors

Zhengbo Chen

Jiejie Hao

Liping Wang

Yi Wang

Fandong Kong

Weiming Zhu

Affiliations

Soon will be listed here.

Abstract

Wailupemycins H (1) and I (2) with a new skeleton coupled two 6-(2-phenylnaphthalene-1-yl)pyrane-2-one nuclei to a -CH2- linkage were identified from the culture of Streptomyces sp. OUCMDZ-3434 associated with the marine algae, Enteromorpha prolifera. Compounds 1 and 2 are two new α-glucosidase inhibitors with the Ki/IC50 values of 16.8/19.7 and 6.0/8.3 μM, respectively. In addition, the absolute configurations of wailupemycins D (3) and E (4) are also resolved in this paper for the first time.

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