Dysregulated Emotion and Trying Substances in Childhood: Insights from a Large Nationally Representative Cohort Study

Overview

Journal Subst Use Misuse

Publisher Informa Healthcare

Date 2023 Aug 12

PMID 37572018

Authors

Robert J Klein

Joseph A Gyorda

Damien Lekkas

Nicholas C Jacobson

Affiliations

Soon will be listed here.

Abstract

Objective: Transdiagnostic perspectives on the shared origins of mental illness posit that dysregulated emotion may represent a key driving force behind multiple forms of psychopathology, including substance use disorders. The present study examined whether a link between dysregulated emotion and trying illicit substances could be observed in childhood.

Method: In a large ( = 7,418) nationally representative sample of children (M = 9.9), individual differences in emotion dysregulation were indexed using child and parent reports of frequency of children's emotional outbursts, as well as children's performance on the emotional N-Back task. Two latent variables, derived from either parental/child-report or performance-based indicators, were evaluated as predictors of having ever tried alcohol, tobacco, or marijuana.

Results: Results showed that reports of dysregulated emotion were linked to a greater likelihood of trying both alcohol and tobacco products. These findings were also present when controlling for individual differences in executive control and socioeconomic status.

Conclusions: These results suggest that well-established links between dysregulated negative emotion and substance use may emerge as early as in childhood and also suggest that children who experience excessive episodes of uncontrollable negative emotion may be at greater risk for trying substances early in life.

References

Stockings E, Hall W, Lynskey M, Morley K, Reavley N, Strang J . Prevention, early intervention, harm reduction, and treatment of substance use in young people. Lancet Psychiatry. 2016; 3(3):280-96. DOI: 10.1016/S2215-0366(16)00002-X. View

Bentler P . Comparative fit indexes in structural models. Psychol Bull. 1990; 107(2):238-46. DOI: 10.1037/0033-2909.107.2.238. View

Verdejo-Garcia A, Bechara A, Recknor E, Perez-Garcia M . Executive dysfunction in substance dependent individuals during drug use and abstinence: an examination of the behavioral, cognitive and emotional correlates of addiction. J Int Neuropsychol Soc. 2006; 12(3):405-15. DOI: 10.1017/s1355617706060486. View

Caldwell L, Schweinsburg A, Nagel B, Barlett V, Brown S, Tapert S . Gender and adolescent alcohol use disorders on BOLD (blood oxygen level dependent) response to spatial working memory. Alcohol Alcohol. 2005; 40(3):194-200. PMC: 2270703. DOI: 10.1093/alcalc/agh134. View

Stanis J, Andersen S . Reducing substance use during adolescence: a translational framework for prevention. Psychopharmacology (Berl). 2014; 231(8):1437-53. PMC: 3969413. DOI: 10.1007/s00213-013-3393-1. View

Chermack S, Giancola P . The relation between alcohol and aggression: an integrated biopsychosocial conceptualization. Clin Psychol Rev. 1997; 17(6):621-49. DOI: 10.1016/s0272-7358(97)00038-x. View

Cheetham A, Allen N, Yucel M, Lubman D . The role of affective dysregulation in drug addiction. Clin Psychol Rev. 2010; 30(6):621-34. DOI: 10.1016/j.cpr.2010.04.005. View

Afuseh E, Pike C, Oruche U . Individualized approach to primary prevention of substance use disorder: age-related risks. Subst Abuse Treat Prev Policy. 2020; 15(1):58. PMC: 7427884. DOI: 10.1186/s13011-020-00300-7. View

Rudolph K, Goin D, Paksarian D, Crowder R, Merikangas K, Stuart E . Causal Mediation Analysis With Observational Data: Considerations and Illustration Examining Mechanisms Linking Neighborhood Poverty to Adolescent Substance Use. Am J Epidemiol. 2018; 188(3):598-608. PMC: 6395164. DOI: 10.1093/aje/kwy248. View

10.

Garavan H, Bartsch H, Conway K, Decastro A, Goldstein R, Heeringa S . Recruiting the ABCD sample: Design considerations and procedures. Dev Cogn Neurosci. 2018; 32:16-22. PMC: 6314286. DOI: 10.1016/j.dcn.2018.04.004. View

11.

Davidson R . Anxiety and affective style: role of prefrontal cortex and amygdala. Biol Psychiatry. 2002; 51(1):68-80. DOI: 10.1016/s0006-3223(01)01328-2. View

12.

Boschloo L, van den Brink W, Penninx B, Wall M, Hasin D . Alcohol-use disorder severity predicts first-incidence of depressive disorders. Psychol Med. 2011; 42(4):695-703. PMC: 3767409. DOI: 10.1017/S0033291711001681. View

13.

Somerville L, Hare T, Casey B . Frontostriatal maturation predicts cognitive control failure to appetitive cues in adolescents. J Cogn Neurosci. 2010; 23(9):2123-34. PMC: 3131482. DOI: 10.1162/jocn.2010.21572. View

14.

Hofmann W, Schmeichel B, Baddeley A . Executive functions and self-regulation. Trends Cogn Sci. 2012; 16(3):174-80. DOI: 10.1016/j.tics.2012.01.006. View

15.

Ennett S, Flewelling R, Lindrooth R, Norton E . School and neighborhood characteristics associated with school rates of alcohol, cigarette, and marijuana use. J Health Soc Behav. 1997; 38(1):55-71. View

16.

Rohde P, Lewinsohn P, Kahler C, Seeley J, BROWN R . Natural course of alcohol use disorders from adolescence to young adulthood. J Am Acad Child Adolesc Psychiatry. 2001; 40(1):83-90. DOI: 10.1097/00004583-200101000-00020. View

17.

Georgie J M, Sean H, Deborah M C, Matthew H, Rona C . Peer-led interventions to prevent tobacco, alcohol and/or drug use among young people aged 11-21 years: a systematic review and meta-analysis. Addiction. 2015; 111(3):391-407. PMC: 4833174. DOI: 10.1111/add.13224. View

18.

Luciana M, Bjork J, Nagel B, Barch D, Gonzalez R, Nixon S . Adolescent neurocognitive development and impacts of substance use: Overview of the adolescent brain cognitive development (ABCD) baseline neurocognition battery. Dev Cogn Neurosci. 2018; 32:67-79. PMC: 6039970. DOI: 10.1016/j.dcn.2018.02.006. View

19.

Turner S, Mota N, Bolton J, Sareen J . Self-medication with alcohol or drugs for mood and anxiety disorders: A narrative review of the epidemiological literature. Depress Anxiety. 2018; 35(9):851-860. PMC: 6175215. DOI: 10.1002/da.22771. View

20.

Griffin K, Botvin G . Evidence-based interventions for preventing substance use disorders in adolescents. Child Adolesc Psychiatr Clin N Am. 2010; 19(3):505-26. PMC: 2916744. DOI: 10.1016/j.chc.2010.03.005. View