Gender and Adolescent Alcohol Use Disorders on BOLD (blood Oxygen Level Dependent) Response to Spatial Working Memory

Overview

Journal Alcohol Alcohol

Publisher Oxford University Press

Specialty Psychiatry

Date 2005 Jan 26

PMID 15668210

Citations 62

Authors

Lisa C Caldwell

Alecia D Schweinsburg

Bonnie J Nagel

Valerie C Barlett

Sandra A Brown

Susan F Tapert

Affiliations

Soon will be listed here.

Abstract

Aims: To determine how alcohol use differentially affects brain functioning in male and female adolescents.

Methods: Adolescents with alcohol use disorders (AUDs; 7 female, 11 male) and control adolescents without AUDs (9 female, 12 male), aged 14-17 years, performed spatial working memory and vigilance tasks during functional magnetic resonance imaging.

Results: Gender, AUD and their interaction were significantly associated with brain activation patterns to the tasks. There were interactions in the superior frontal, superior temporal, cingulate and fusiform regions, in which female and male adolescents with AUDs showed a different brain response from each other and control subjects. Overall, female adolescents with AUDs showed a greater departure from normal activation patterns than male adolescents with AUD.

Conclusions: Adolescent alcohol involvement may affect male and female brains differently, and adolescent females may be somewhat more vulnerable to adverse alcohol effects. With continued drinking, these adolescents may be at an increased risk for behavioural deficits.

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