Human Oestrogen Receptor CDNA: Sequence, Expression and Homology to V-erb-A

Overview

Journal Nature

Specialty Science

Date 1986 Mar 13

PMID 3754034

Citations 480

Authors

S Green

P Walter

V Kumar

A Krust

J M Bornert

P Argos

P Chambon

Affiliations

Soon will be listed here.

Abstract

We have cloned and sequenced the complete complementary DNA of the oestrogen receptor (ER) present in the breast cancer cell line MCF-7. The expression of the ER cDNA in HeLa cells produces a protein that has the same relative molecular mass and binds oestradiol with the same affinity as the MCF-7 ER. There is extensive homology between the ER and the erb-A protein of the oncogenic avian erythroblastosis virus.

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