Freeze-fracture Cytochemistry of Wheat Germ Agglutinin and Concanavalin A Receptors on the Plasma Membrane of Normal, Bernard-Soulier, and Thrombasthenic Platelets

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1986 Feb 1

PMID 3753826

Citations 1

Authors

J Chevalier

J P Caen

P Pinto da Silva

Affiliations

Soon will be listed here.

Abstract

The authors report here the results of fracture-labeling of wheat germ agglutinin (WGA) and concanavalin A (Con A) receptors on the plasma membranes of normal, Bernard-Soulier, and thrombasthenic platelets. In all cases, virtually all of the label was confined to the exoplasmic half of the membrane. Despite the absence of GP Ib in Bernard-Soulier platelets and the absence or strong reduction of Gp IIb and GP IIIa in thrombasthenic platelets, their plasma membranes were strongly labeled by both Con A and WGA. These results are best accounted for by the presence of other glycoproteins and/or glycolipids at the platelet surface.

Citing Articles

Distribution of glycoconjugates on the plasma membrane and on membranes of the open-canalicular system in human platelets. A cytochemical study.

Kawakami H, Hirano H Histochemistry. 1989; 91(1):1-4.

PMID: 2925444 DOI: 10.1007/BF00501902.

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