Early Vascular Ageing in Adolescents with Migraine with Aura: a Community-based Study

Overview

Journal BMC Cardiovasc Disord

Publisher Biomed Central

Specialty Cardiology & Vascular Diseases

Date 2023 Aug 1

PMID 37528337

Authors

Benoit Bernar

Nina Gande

Anna Katharina Stock

Anna Staudt

Raimund Pechlaner

Christoph Hochmayr

Katharina Kaltseis

Bernhard Winder

Sophia Julia J Kiechl

Gregor Broessner

Ralf Geiger

Stefan Kiechl

Ursula Kiechl-Kohlendorfer

Michael Knoflach

Affiliations

Soon will be listed here.

Abstract

Background: Migraine with aura is associated with an increased risk of cardiovascular disease, yet the pathophysiology is unknown. Suggested underlying mechanisms of aura formation point into the direction of an abnormal vasoreactivity that also extends to the extracranial vasculature.

Methods: In the Early Vascular Ageing Tyrol study, a community-based non-randomized controlled trial conducted in 45 schools and companies in Tyrol (Austria) and South-Tyrol (Italy) between May 2015 and September 2018 aiming to increase cardiovascular health in adolescents, headache syndromes were classified according to the International Classification of Headache Disorders in a face-to-face interview. Carotid-femoral pulse-wave-velocity was measured by applanation tonometry and carotid intima-media-thickness by high-resolution ultrasound of the distal common carotid arteries. Differences in pulse-wave-velocity and carotid intima-media-thickness in youngsters with migraine with aura were compared respectively to those without headache and with other headaches by multivariable linear regression analysis.

Results: Of the 2102 study participants 1589 were aged 14 to 19 (mean 16.8) years and had complete data. 43 (2.7%) reported migraine with aura and 737 (46.4%) other headaches. Mean pulse-wave-velocity was 6.17 m/s (± 0.85) for migraine with aura, 6.06 m/s (± 0.82) for all other headaches and 6.15 (0.95) m/s for participants without headaches. Carotid intima-media-thickness was 411.3 µm (± 43.5) for migraine with aura, 410.9 µm (± 46.0) for all other headaches and 421.6 µm (± 48.4) for participants without headaches. In multivariable linear regression analysis, we found no differences in carotid-femoral pulse-wave-velocity or carotid intima-media-thickness in young subjects with migraine with aura, all other headaches, or no headaches.

Conclusions: In line with previous large-scale studies in adults, we could not demonstrate relevant associations of migraine with aura with markers of arterial stiffness or subclinical atherosclerosis making early vascular ageing an unlikely pathophysiological link between migraine with aura and cardiovascular diseases.

Trial Registration: First registered on ClinicalTrials.gov 29/04/2019 (NCT03929692).

Citing Articles

The prevalence and associated factors for primary headache disorders in adolescents in eastern Sudan: a community-based cross-sectional study.

Omar S, Osman O, Al-Nafeesah A, AlEed A, Alfaifi J, Adam I Front Neurol. 2024; 15:1373890.

PMID: 38694780 PMC: 11061350. DOI: 10.3389/fneur.2024.1373890.

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